Muraglitazar glucuronide | CAS# 875430-26-5 | Biochemical

MedKoo Cat#: 577815 | Name: Muraglitazar glucuronide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Muraglitazar glucuronide is a Peroxime Proliferator Activated (PPAR) Agonist that has glucose- and lipid-lowering activities.

Chemical Structure

Muraglitazar glucuronide

CAS#875430-26-5

Theoretical Analysis

MedKoo Cat#: 577815

Name: Muraglitazar glucuronide

CAS#: 875430-26-5

Chemical Formula: C35H36N2O13

Exact Mass: 692.2217

Molecular Weight: 692.67

Elemental Analysis: C, 60.69; H, 5.24; N, 4.04; O, 30.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Muraglitazar glucuronide; Muraglitazar metabolite M13

IUPAC/Chemical Name

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((N-((4-methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

InChi Key

VLMNHAOSAKQBJM-WKRHDJAJSA-N

InChi Code

1S/C35H36N2O13/c1-20-26(36-32(47-20)22-6-4-3-5-7-22)16-17-46-24-10-8-21(9-11-24)18-37(35(44)48-25-14-12-23(45-2)13-15-25)19-27(38)49-34-30(41)28(39)29(40)31(50-34)33(42)43/h3-15,28-31,34,39-41H,16-19H2,1-2H3,(H,42,43)/t28-,29-,30+,31-,34+/m0/s1

SMILES Code

COc1ccc(OC(=O)N(CC(=O)O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(=O)O)Cc3ccc(OCCc4nc(oc4C)c5ccccc5)cc3)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 692.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Coletta DK, Fernandez M, Cersosimo E, Gastaldelli A, Musi N, DeFronzo RA. The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo. Diabet Med. 2015 May;32(5):657-64. doi: 10.1111/dme.12664. Epub 2015 Jan 7. PubMed PMID: 25484175. 2: Paukkeri EL, Leppänen T, Lindholm M, Yam MF, Asmawi MZ, Kolmonen A, Aulaskari PH, Moilanen E. Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models. Arthritis Res Ther. 2013 Apr 17;15(2):R51. doi: 10.1186/ar4211. PubMed PMID: 23594962; PubMed Central PMCID: PMC4060226. 3: Fernandez M, Gastaldelli A, Triplitt C, Hardies J, Casolaro A, Petz R, Tantiwong P, Musi N, Cersosimo E, Ferrannini E, DeFronzo RA. Metabolic effects of muraglitazar in type 2 diabetic subjects. Diabetes Obes Metab. 2011 Oct;13(10):893-902. doi: 10.1111/j.1463-1326.2011.01429.x. PubMed PMID: 21615671.