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MedKoo Cat#: 584527 | Name: KS I

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KS I is a gonadotropin antagonist and is a cyclolignan isolated from extracts of Lycopus and Lithosperum after oxidation with caffeic acid.

Chemical Structure

KS I
KS I
CAS#130752-21-5

Theoretical Analysis

MedKoo Cat#: 584527

Name: KS I

CAS#: 130752-21-5

Chemical Formula: C18H14O8

Exact Mass: 358.0689

Molecular Weight: 358.30

Elemental Analysis: C, 60.34; H, 3.94; O, 35.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KS I; KSI; KS-I
IUPAC/Chemical Name
2,3-Naphthalenedicarboxylic acid, 1-(3,4-dihydroxyphenyl)-1,2-dihydro-6,7-dihydroxy-
InChi Key
WJMFXQBNYLYADA-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14O8/c19-11-2-1-7(4-12(11)20)15-9-6-14(22)13(21)5-8(9)3-10(17(23)24)16(15)18(25)26/h1-6,15-16,19-22H,(H,23,24)(H,25,26)
SMILES Code
O=C(C1C(C2=CC=C(O)C(O)=C2)C3=C(C=C(O)C(O)=C3)C=C1C(O)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu LT, Chen-Izu Y. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov;466(11):2067-76. doi: 10.1007/s00424-014-1465-7. Epub 2014 Feb 19. PubMed PMID: 24535581; PubMed Central PMCID: PMC4138296. 2: Berenfeld O. The Major Role of I(K1) in Mechanisms of Rotor Drift in the Atria: A Computational Study. Clin Med Insights Cardiol. 2016 Dec 20;10(Suppl 1):71-79. doi: 10.4137/CMC.S39773. eCollection 2016. PubMed PMID: 28096699; PubMed Central PMCID: PMC5175588. 3: Liu T, Traebert M, Ju H, Suter W, Guo D, Hoffmann P, Kowey PR, Yan GX. Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation. Heart Rhythm. 2012 Oct;9(10):1706-15. doi: 10.1016/j.hrthm.2012.06.030. Epub 2012 Jun 16. PubMed PMID: 22710481. 4: Vakhitova IuV, Farafontova EI, Khisamutdinova RIu, Iunusov VM, Cypasheva IP, Iunusov MS. [To the mechanisms of antiarrhythmic action of Allapinine]. Bioorg Khim. 2013 Jan-Feb;39(1):105-16. Russian. PubMed PMID: 23844512. 5: Henrion U, Zumhagen S, Steinke K, Strutz-Seebohm N, Stallmeyer B, Lang F, Schulze-Bahr E, Seebohm G. Overlapping cardiac phenotype associated with a familial mutation in the voltage sensor of the KCNQ1 channel. Cell Physiol Biochem. 2012;29(5-6):809-18. doi: 10.1159/000178470. Epub 2012 May 11. PubMed PMID: 22613981. 6: Missan S, Linsdell P, McDonald TF. Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes. Pflugers Arch. 2008 Jun;456(3):489-500. Epub 2007 Dec 21. PubMed PMID: 18097684. 7: Mitcheson JS, Sanguinetti MC. Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels. Cell Physiol Biochem. 1999;9(4-5):201-16. Review. PubMed PMID: 10575198. 8: Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K. Keratan sulfate restricts neural plasticity after spinal cord injury. J Neurosci. 2011 Nov 23;31(47):17091-102. doi: 10.1523/JNEUROSCI.5120-10.2011. PubMed PMID: 22114278. 9: Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura H, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of I (Ks) current in guinea pig atrium. Pflugers Arch. 2009 Sep;458(5):837-49. doi: 10.1007/s00424-009-0669-8. Epub 2009 Apr 29. PubMed PMID: 19404674. 10: Lee HA, Kim KS, Park SJ, Kim EJ. Cellular mechanism of the QT prolongation induced by sulpiride. Int J Toxicol. 2009 May-Jun;28(3):207-12. doi: 10.1177/1091581809337261. PubMed PMID: 19546258. 11: Shibata S, Ono K, Iijima T. Sevoflurane inhibition of the slowly activating delayed rectifier K+ current in guinea pig ventricular cells. J Pharmacol Sci. 2004 Jul;95(3):363-73. PubMed PMID: 15272213. 12: Champeroux P, Ouillé A, Martel E, Fowler JS, Maurin A, Richard S, Le Guennec JY. A step towards characterisation of electrophysiological profile of torsadogenic drugs. J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):269-78. doi: 10.1016/j.vascn.2011.01.001. Epub 2011 Jan 9. PubMed PMID: 21224008. 13: Akhrem AA, Bel'skiĭ SM, Metelitsa DI. [Effect of temperature on the interaction of cytochrome P-450 with a variety of amines]. Biokhimiia. 1977 Dec;42(12):2116-20. Russian. PubMed PMID: 597514. 14: Kathofer S, Thomas D, Karle CA. The novel antiarrhythmic drug dronedarone: comparison with amiodarone. Cardiovasc Drug Rev. 2005 Fall;23(3):217-30. Review. PubMed PMID: 16252015. 15: Minamisawa T, Suzuki K, Hirabayashi J. Multistage mass spectrometric sequencing of keratan sulfate-related oligosaccharides. Anal Chem. 2006 Feb 1;78(3):891-900. PubMed PMID: 16448065. 16: Serraino D, Cerimele D, Piselli P, Aztori L, Farchi F, Carletti F, Navarra A, Masala MV, Rezza G. Infection with human herpesvirus type 8 and Kaposi's sarcoma in Sardinia. Infection. 2006 Feb;34(1):39-42. PubMed PMID: 16501902. 17: Peng S, Lacerda AE, Kirsch GE, Brown AM, Bruening-Wright A. The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes. J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):277-86. doi: 10.1016/j.vascn.2010.01.014. Epub 2010 Feb 11. PubMed PMID: 20153443. 18: Torres-Jacome J, Gallego M, Rodríguez-Robledo JM, Sanchez-Chapula JA, Casis O. Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes. Acta Physiol (Oxf). 2013 Mar;207(3):447-59. doi: 10.1111/apha.12043. Epub 2012 Dec 27. PubMed PMID: 23181465. 19: Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17828-33. Epub 2005 Nov 30. PubMed PMID: 16319223; PubMed Central PMCID: PMC1297712. 20: Stramba-Badiale M, Priori SG, Napolitano C, Locati EH, Viñolas X, Haverkamp W, Schulze-Bahr E, Goulene K, Schwartz PJ. Gene-specific differences in the circadian variation of ventricular repolarization in the long QT syndrome: a key to sudden death during sleep? Ital Heart J. 2000 May;1(5):323-8. PubMed PMID: 10832806.

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