Paltusotine, also known as CRN00808, is a somatostatin receptor agonist. Paltusotine showed no direct inhibition of major cytochrome P450 enzymes or the hERG ion channel and had sufficient exposure in rats and excellent exposure in dogs upon oral dosing. In pharmacodynamic studies, Paltusotine dose-dependently suppressed growth hormone (GH) secretion induced by an exogenous growth-hormone-releasing hormone (GHRH) challenge in both male and female rats following a single oral dose and suppressed IGF-1 levels with repeated oral administration in both rats and dogs.
MedKoo Cat#: 414745
Name: Paltusotine HCl
CAS#: 2172875-40-8 (2HCl)
Chemical Formula: C27H24Cl2F2N4O
Exact Mass:
Molecular Weight: 529.41
Elemental Analysis: C, 61.26; H, 4.57; Cl, 13.39; F, 7.18; N, 10.58; O, 3.02
The following data is based on the product molecular weight 529.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
