Hydroquinone monobenzoate | CAS# 2444-19-1 | Biochemical

MedKoo Cat#: 576449 | Name: Hydroquinone monobenzoate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroquinone monobenzoate is an oxidoreductant and potential topoisomerase II inhibitor commercially used in skin whitening treatments and photography development. It may induce DNA damage.

Chemical Structure

Hydroquinone monobenzoate

CAS#2444-19-1

Theoretical Analysis

MedKoo Cat#: 576449

Name: Hydroquinone monobenzoate

CAS#: 2444-19-1

Chemical Formula: C13H10O3

Exact Mass: 214.0630

Molecular Weight: 214.22

Elemental Analysis: C, 72.89; H, 4.71; O, 22.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hydroquinone monobenzoate

IUPAC/Chemical Name

p-Hydroxyphenyl benzoate

InChi Key

JFAXJRJMFOACBO-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H10O3/c14-11-6-8-12(9-7-11)16-13(15)10-4-2-1-3-5-10/h1-9,14H

SMILES Code

Oc1ccc(OC(=O)c2ccccc2)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 214.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jiang C, Garg S, Waite TD. Hydroquinone-Mediated Redox Cycling of Iron and Concomitant Oxidation of Hydroquinone in Oxic Waters under Acidic Conditions: Comparison with Iron-Natural Organic Matter Interactions. Environ Sci Technol. 2015 Dec 15;49(24):14076-84. doi: 10.1021/acs.est.5b03189. Epub 2015 Dec 2. PubMed PMID: 26579728. 2: Perotti EB. Impact of hydroquinone used as a redox effector model on potential denitrification, microbial activity and redox condition of a cultivable soil. Rev Argent Microbiol. 2015 Jul-Sep;47(3):212-8. doi: 10.1016/j.ram.2015.06.003. Epub 2015 Sep 9. PubMed PMID: 26364186. 3: Jeon JS, Kim BH, Lee SH, Kwon HJ, Bae HJ, Kim SK, Park JA, Shim JH, Abd El-Aty AM, Shin HC. Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high-performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition. Int J Cosmet Sci. 2015 Dec;37(6):567-73. doi: 10.1111/ics.12228. Epub 2015 May 7. PubMed PMID: 25857400. 4: Adalatkhah H, Sadeghi-Bazargani H. The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. Drug Des Devel Ther. 2015 Aug 4;9:4219-25. doi: 10.2147/DDDT.S80713. eCollection 2015. PubMed PMID: 26345129; PubMed Central PMCID: PMC4531037. 5: Ibrahim ZA, Gheida SF, El Maghraby GM, Farag ZE. Evaluation of the efficacy and safety of combinations of hydroquinone, glycolic acid, and hyaluronic acid in the treatment of melasma. J Cosmet Dermatol. 2015 Jun;14(2):113-23. doi: 10.1111/jocd.12143. Epub 2015 Apr 6. PubMed PMID: 25847063. 6: North M, Shuga J, Fromowitz M, Loguinov A, Shannon K, Zhang L, Smith MT, Vulpe CD. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer. 2014 Jan 5;14:6. doi: 10.1186/1471-2407-14-6. PubMed PMID: 24386979; PubMed Central PMCID: PMC3898384. 7: Yu CH, Suriguga, Li Y, Li YR, Tang KY, Jiang L, Yi ZC. The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation. Biomed Environ Sci. 2014 Mar;27(3):212-4. doi: 10.3967/bes2014.043. PubMed PMID: 24709103. 8: Banihashemi M, Zabolinejad N, Jaafari MR, Salehi M, Jabari A. Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma. J Cosmet Dermatol. 2015 Sep;14(3):174-7. doi: 10.1111/jocd.12152. Epub 2015 Jul 14. PubMed PMID: 26177992. 9: Ramsden CA, Riley PA. Mechanistic aspects of the tyrosinase oxidation of hydroquinone. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2463-4. doi: 10.1016/j.bmcl.2014.04.009. Epub 2014 Apr 13. PubMed PMID: 24767847. 10: Urra FA, Córdova-Delgado M, Lapier M, Orellana-Manzano A, Acevedo-Arévalo L, Pessoa-Mahana H, González-Vivanco JM, Martínez-Cifuentes M, Ramírez-Rodríguez O, Millas-Vargas JP, Weiss-López B, Pavani M, Ferreira J, Araya-Maturana R. Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicol Appl Pharmacol. 2016 Jan 15;291:46-57. doi: 10.1016/j.taap.2015.12.005. Epub 2015 Dec 19. PubMed PMID: 26712467.