L-054264 | CAS#208706-12-1 | SSTR2 agonist

MedKoo Cat#: 130011 | Name: L-054264

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-054264 is an SSTR2 agonist that has been shown to reduce the expression of fear in rats, but not fear acquisition itself.

Chemical Structure

L-054264

CAS#208706-12-1

Theoretical Analysis

MedKoo Cat#: 130011

Name: L-054264

CAS#: 208706-12-1

Chemical Formula: C33H41N5O2

Exact Mass: 539.3260

Molecular Weight: 539.72

Elemental Analysis: C, 73.44; H, 7.66; N, 12.98; O, 5.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L-054264; L054264; L 054264; L-054,264

IUPAC/Chemical Name

N-((R)-3-(1H-indol-3-yl)-1-(methyl((1R,3S)-3-(methylamino)cyclohexyl)amino)-1-oxopropan-2-yl)spiro[indene-1,4'-piperidine]-1'-carboxamide

InChi Key

JHPJTVLDEHDVOR-LUXHBGHRSA-N

InChi Code

InChI=1S/C33H41N5O2/c1-34-25-9-7-10-26(21-25)37(2)31(39)30(20-24-22-35-29-13-6-4-11-27(24)29)36-32(40)38-18-16-33(17-19-38)15-14-23-8-3-5-12-28(23)33/h3-6,8,11-15,22,25-26,30,34-35H,7,9-10,16-21H2,1-2H3,(H,36,40)/t25-,26+,30+/m0/s1

SMILES Code

O=C(N1CCC2(CC1)C=CC3=C2C=CC=C3)N[C@H](CC4=CNC5=C4C=CC=C5)C(N([C@H]6C[C@@H](NC)CCC6)C)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 539.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kahl E, Fendt M. Injections of the somatostatin receptor type 2 agonist L-054,264 into the amygdala block expression but not acquisition of conditioned fear in rats. Behav Brain Res. 2014 May 15;265:49-52. doi: 10.1016/j.bbr.2014.02.011. Epub 2014 Feb 15. PMID: 24548855. 2. Yang L, Guo L, Pasternak A, Mosley R, Rohrer S, Birzin E, Foor F, Cheng K, Schaeffer J, Patchett AA. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. doi: 10.1021/jm980194h. PMID: 9632348. 3. Vuong HE, Hardi CN, Barnes S, Brecha NC. Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina. J Neurosci. 2015 Dec 2;35(48):15955-70. doi: 10.1523/JNEUROSCI.3382-15.2015. PMID: 26631476; PMCID: PMC4666919.