XD2-149 is a napabucasin-based proteolysis targeting chimera (PROTAC). XD2-149 resulted in inhibition of STAT3 signaling in pancreatic cancer cell lines without inducing proteasome-dependent degradation of STAT3. Proteomics analysis of XD2-149 revealed the downregulation of the E3 ubiquitinprotein ligase ZFP91. XD2-149 degrades ZFP91 with DC50 values in the nanomolar range.
MedKoo Cat#: 463964
Name: XD2-149
CAS#: unknown
Chemical Formula: C38H39N5O8
Exact Mass: 693.2799
Molecular Weight: 693.76
Elemental Analysis: C, 65.79; H, 5.67; N, 10.10; O, 18.45
The following data is based on the product molecular weight 693.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
