MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561635 | Name: Isosorbide
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isosorbide is a precursor of Isosorbide mononitrate or dinitrate, which relax vascular smooth muscle by formation of the free radical nitric oxide (NO).

Chemical Structure

Isosorbide
Isosorbide
CAS#652-67-5

Theoretical Analysis

MedKoo Cat#: 561635

Name: Isosorbide

CAS#: 652-67-5

Chemical Formula: C6H10O4

Exact Mass: 146.0579

Molecular Weight: 146.14

Elemental Analysis: C, 49.31; H, 6.90; O, 43.79

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 Weeks
100g USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Isosorbide; Devicoran; Hydronol; Ismotic; Isobide;
IUPAC/Chemical Name
(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-Hexahydrofuro[3,2-b]furan-3,6-diol
InChi Key
KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChi Code
InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES Code
O[C@@H]1[C@](OC[C@H]2O)([H])[C@]2([H])OC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 146.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Institute for Quality and Efficiency in Health Care. Systematic Guideline Search and Appraisal, as Well as Extraction of Relevant Recommendations, for a DMP "Chronic Heart Failure" [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2015 Nov 19. Available from http://www.ncbi.nlm.nih.gov/books/NBK458452/ PubMed PMID: 29144671. 2: Vogel JP, Osoti AO, Kelly AJ, Livio S, Norman JE, Alfirevic Z. Pharmacological and mechanical interventions for labour induction in outpatient settings. Cochrane Database Syst Rev. 2017 Sep 13;9:CD007701. doi: 10.1002/14651858.CD007701.pub3. Review. PubMed PMID: 28901007. 3: Jia Y, Leung SW. How Efficacious is Danshen (Salvia miltiorrhiza) Dripping Pill in Treating Angina Pectoris? Evidence Assessment for Meta-Analysis of Randomized Controlled Trials. J Altern Complement Med. 2017 Sep;23(9):676-684. doi: 10.1089/acm.2017.0069. Epub 2017 Jun 26. Review. PubMed PMID: 28650203. 4: Aronow WS. Treatment of Heart Failure with Abnormal Left Ventricular Systolic Function in Older Adults. Heart Fail Clin. 2017 Jul;13(3):467-483. doi: 10.1016/j.hfc.2017.02.004. Review. PubMed PMID: 28602366. 5: West HM, Jozwiak M, Dodd JM. Methods of term labour induction for women with a previous caesarean section. Cochrane Database Syst Rev. 2017 Jun 9;6:CD009792. doi: 10.1002/14651858.CD009792.pub3. Review. PubMed PMID: 28599068. 6: Aricò F, Tundo P. Isosorbide and dimethyl carbonate: a green match. Beilstein J Org Chem. 2016 Oct 26;12:2256-2266. doi: 10.3762/bjoc.12.218. eCollection 2016. Review. PubMed PMID: 28144292; PubMed Central PMCID: PMC5238621. 7: Ghosh A, Lattey KR, Kelly AJ. Nitric oxide donors for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2016 Dec 5;12:CD006901. doi: 10.1002/14651858.CD006901.pub3. Review. PubMed PMID: 27918616. 8: Miyashita H, Worthington HV, Qualtrough A, Plasschaert A. WITHDRAWN: Pulp management for caries in adults: maintaining pulp vitality. Cochrane Database Syst Rev. 2016 Nov 28;11:CD004484. Review. PubMed PMID: 27892627. 9: Raj L, Adhyaru B. An evidence-based review of recent advances in therapy for heart failure with reduced ejection fraction (HFrEF). Postgrad Med J. 2016 Dec;92(1094):726-734. doi: 10.1136/postgradmedj-2016-134378. Epub 2016 Oct 5. Review. PubMed PMID: 27708003. 10: Aronow WS. Current treatment of heart failure with reduction of left ventricular ejection fraction. Expert Rev Clin Pharmacol. 2016 Dec;9(12):1619-1631. Epub 2016 Oct 11. Review. PubMed PMID: 27673415. 11: Zhao N, Xu J, Singh B, Yu X, Wu T, Huang Y. Nitrates for the prevention of cardiac morbidity and mortality in patients undergoing non-cardiac surgery. Cochrane Database Syst Rev. 2016 Aug 4;(8):CD010726. doi: 10.1002/14651858.CD010726.pub2. Review. PubMed PMID: 27488764. 12: Snyder MJ, Gibbs LM, Lindsay TJ. Treating Painful Diabetic Peripheral Neuropathy: An Update. Am Fam Physician. 2016 Aug 1;94(3):227-34. Review. PubMed PMID: 27479625. 13: Badve SV, Palmer SC, Strippoli GFM, Roberts MA, Teixeira-Pinto A, Boudville N, Cass A, Hawley CM, Hiremath SS, Pascoe EM, Perkovic V, Whalley GA, Craig JC, Johnson DW. The Validity of Left Ventricular Mass as a Surrogate End Point for All-Cause and Cardiovascular Mortality Outcomes in People With CKD: A Systematic Review and Meta-analysis. Am J Kidney Dis. 2016 Oct;68(4):554-563. doi: 10.1053/j.ajkd.2016.03.418. Epub 2016 Apr 30. Review. PubMed PMID: 27138469. 14: Naegele M, Flammer AJ, Enseleit F, Ruschitzka F. Medical therapy of heart failure with reduced ejection fraction: current evidence and new developments. Swiss Med Wkly. 2016 Mar 11;146:w14295. doi: 10.4414/smw.2016.14295. eCollection 2016. Review. PubMed PMID: 26968014. 15: Crowson MG, Patki A, Tucci DL. A Systematic Review of Diuretics in the Medical Management of Ménière's Disease. Otolaryngol Head Neck Surg. 2016 May;154(5):824-34. doi: 10.1177/0194599816630733. Epub 2016 Mar 1. Review. PubMed PMID: 26932948. 16: Owens AT, Brozena SC, Jessup M. New Management Strategies in Heart Failure. Circ Res. 2016 Feb 5;118(3):480-95. doi: 10.1161/CIRCRESAHA.115.306567. Review. PubMed PMID: 26846642. 17: Webber K, Grivell RM. Cervical ripening before first trimester surgical evacuation for non-viable pregnancy. Cochrane Database Syst Rev. 2015 Nov 10;(11):CD009954. doi: 10.1002/14651858.CD009954.pub2. Review. PubMed PMID: 26559875. 18: Zia KM, Noreen A, Zuber M, Tabasum S, Mujahid M. Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review. Int J Biol Macromol. 2016 Jan;82:1028-40. doi: 10.1016/j.ijbiomac.2015.10.040. Epub 2015 Oct 19. Review. PubMed PMID: 26492854. 19: Kwok CS, Rashid M, Fraser D, Nolan J, Mamas M. Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies. Cardiovasc Revasc Med. 2015 Dec;16(8):484-90. doi: 10.1016/j.carrev.2015.08.008. Epub 2015 Aug 15. Review. PubMed PMID: 26365608. 20: Daiber A, Münzel T. Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress. Antioxid Redox Signal. 2015 Oct 10;23(11):899-942. doi: 10.1089/ars.2015.6376. Epub 2015 Sep 24. Review. PubMed PMID: 26261901; PubMed Central PMCID: PMC4752190.

View History

Ofornine

Ofornine