BMS-986176, also known as LX9211, is a highly selective, CNS penetrant, potent AAK1 inhibitor from a novel class of bi(hetero)aryl ethers. BMS-986176/LX9211 (34) showed excellent efficacy in two rodent neuropathic pain models and excellent central nervous system (CNS) penetration and target engagement at the spinal cord with an average brain to plasma ratio of 20 in rat. The compound exhibited favorable physicochemical and pharmacokinetic properties, had an acceptable preclinical toxicity profile, and was chosen for clinical trials.
MedKoo Cat#: 556066
Name: BMS-986176
CAS#: 1815613-42-3
Chemical Formula: C19H23F4N3O
Exact Mass: 385.1777
Molecular Weight: 385.41
Elemental Analysis: C, 59.21; H, 6.02; F, 19.72; N, 10.90; O, 4.15
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 220.0 | 570.83 |
The following data is based on the product molecular weight 385.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
