MedKoo Cat#: 598439 | Name: Laudexium methylsulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Chemical Structure

Laudexium methylsulfate
Laudexium methylsulfate
CAS#3253-60-9

Theoretical Analysis

MedKoo Cat#: 598439

Name: Laudexium methylsulfate

CAS#: 3253-60-9

Chemical Formula: C54H80N2O16S2

Exact Mass:

Molecular Weight: 1077.35

Elemental Analysis: C, 60.20; H, 7.49; N, 2.60; O, 23.76; S, 5.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Laudexium methylsulfate; Laudexium; Laudolissin methosulphate;
IUPAC/Chemical Name
2,2'-(decane-1,10-diyl)bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) methyl sulfate
InChi Key
LADQAYSLFLCKOD-UHFFFAOYSA-L
InChi Code
InChI=1S/C52H74N2O8.2CH4O4S/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44H,11-18,23-30H2,1-10H3;2*1H3,(H,2,3,4)/q+2;;/p-2
SMILES Code
COC1=CC(CC2[N+](CCCCCCCCCC[N+]3(C)C(CC4=CC=C(OC)C(OC)=C4)C5=C(C=C(OC)C(OC)=C5)CC3)(C)CCC6=C2C=C(OC)C(OC)=C6)=CC=C1OC.O=S(OC)([O-])=O.O=S(OC)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,077.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: BRITTAIN RT, CHESHER BG, COLLIER HO, GRIMSHAW JJ. Assay of suxamethonium and laudexium on the frog rectus abdominis. Br J Pharmacol Chemother. 1959 Jun;14(2):158-63. PubMed PMID: 13662566; PubMed Central PMCID: PMC1481804. 2: COLLIER HO, MACAULEY B. The effects on animals of large doses of laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):237-44. PubMed PMID: 13172370. 3: BROWN LH. Failure to detect anticholinesterase activity in laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):244-5. PubMed PMID: 13172371. 4: HUNTER AR. The action of laudexium in man and experimental animals. Br J Anaesth. 1955 Feb;27(2):73-9. PubMed PMID: 13230365. 5: STEAD AL, ANDREWS WH. The role of the canine liver in the detoxication of d-tubocurarine chloride, gallamine triethiodide and laudexium. Br J Anaesth. 1957 Apr;29(4):151-5. PubMed PMID: 13426356.