AL-GDa62 is is a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. AL-GDa62 preferentially induced apoptosis in CDH1−/− cells, and Cdh1−/− mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations. Thermal proteome profiling of treated MCF10A-CDH1−/− cell protein lysates revealed that AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9. In vitro, AL-GDa62 inhibited SUMOylation at low micromolar concentrations.
MedKoo Cat#: 465720
Name: AL-GDa62
CAS#: unknown
Chemical Formula: C24H28FN3O
Exact Mass: 393.2216
Molecular Weight: 393.51
Elemental Analysis: C, 73.26; H, 7.17; F, 4.83; N, 10.68; O, 4.07
The following data is based on the product molecular weight 393.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
