MedKoo Cat#: 413613 | Name: Dexlofexidine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexlofexidine Free Base is an isomer “+“ of lofexidine, which is an agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine

Chemical Structure

Dexlofexidine Free Base
Dexlofexidine Free Base
CAS#81447-79-2 (free base)

Theoretical Analysis

MedKoo Cat#: 413613

Name: Dexlofexidine Free Base

CAS#: 81447-79-2 (free base)

Chemical Formula: C11H12Cl2N2O

Exact Mass: 258.0327

Molecular Weight: 259.13

Elemental Analysis: C, 50.99; H, 4.67; Cl, 27.36; N, 10.81; O, 6.17

Price and Availability

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Synonym
Dexlofexidine Free Base; Dexlofexidinum; (S)-Lofexidine; (-)-Lofexidine; dexlofexidina;
IUPAC/Chemical Name
(+)-(S)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline
InChi Key
KSMAGQUYOIHWFS-ZETCQYMHSA-N
InChi Code
InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)/t7-/m0/s1
SMILES Code
C[C@@H](C1=NCCN1)OC2=C(Cl)C=CC=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 259.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wilffert B, Mathy MJ, Batink HD, de Jonge A, Thoolen MJ, Prop G, Graf E, Timmermans PB, van Zwieten PA. Interference of enantiomers of lofexidine with alpha-adrenoceptors. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):18-32. PMID: 2988468. 2: Biedermann J, León-Lomelí A, Borbe HO, Prop G. Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities. J Med Chem. 1986 Jul;29(7):1183-8. doi: 10.1021/jm00157a011. PMID: 2879913.