Dexlofexidine HCl | CAS# 87858-98-8 (HCl) | agonist of alpha 2-adrenoceptor

MedKoo Cat#: 413614 | Name: Dexlofexidine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexlofexidine HCl is the salt form of Dexlofexidine Free Base, an isomer “+“ of lofexidine, which is an agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine.

Chemical Structure

Dexlofexidine HCl

CAS#87858-98-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 413614

Name: Dexlofexidine HCl

CAS#: 87858-98-8 (HCl)

Chemical Formula: C11H13Cl3N2O

Exact Mass: 294.0093

Molecular Weight: 295.59

Elemental Analysis: C, 44.70; H, 4.43; Cl, 35.98; N, 9.48; O, 5.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

81447-79-2 (free base) 87858-98-8 (HCl)

Synonym

Dexlofexidine HCl; Lofexidine hydrochloride; Dexlofexidine hydrochloride; Lofexidine hydrochloride, (S)-; Lofexidine hydrochloride, (+)-;

IUPAC/Chemical Name

1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, monohydrochloride, (S)-

InChi Key

DWWHMKBNNNZGHF-FJXQXJEOSA-N

InChi Code

InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H/t7-;/m0./s1

SMILES Code

C[C@@H](C1=NCCN1)OC2=C(Cl)C=CC=C2Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 295.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wilffert B, Mathy MJ, Batink HD, de Jonge A, Thoolen MJ, Prop G, Graf E, Timmermans PB, van Zwieten PA. Interference of enantiomers of lofexidine with alpha-adrenoceptors. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):18-32. PMID: 2988468. 2: Biedermann J, León-Lomelí A, Borbe HO, Prop G. Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities. J Med Chem. 1986 Jul;29(7):1183-8. doi: 10.1021/jm00157a011. PMID: 2879913.