NV669 is an aminosterol derived from squalamine found to possess strong anticancer effects. NV669 inhibited the viability of cancer cells, induced cell cycle arrest and subsequently promoted apoptosis. NV669 inhibits the proliferation of pancreatic and hepatic cancer cells through the regulation of G2/M phase transition via the cyclin B1-Cdk1 complex. In vitro NV669 inhibits PTP1B activity and FAK expression. NV669 impacts on the expression of adhesion molecules CDH-1, -2 and -3 in BxPC3 and Huh7 lines that form cell monolayers. NV669 may serve as an alternative anticancer agent, used alone or in association with other medications, for the treatment of pancreatic adenocarcinoma and hepatocellular carcinoma.
MedKoo Cat#: 465610
Name: NV669
CAS#: unknown
Chemical Formula: C37H70N4O
Exact Mass: 586.5550
Molecular Weight: 586.99
Elemental Analysis: C, 75.71; H, 12.02; N, 9.54; O, 2.73
The following data is based on the product molecular weight 586.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
