MedKoo Cat#: 562714 | Name: myomiR-IN-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

myomiR-IN-1 is an inhibitor of myomiRs. It acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating expression of differentiation markers.

Chemical Structure

myomiR-IN-1
myomiR-IN-1
CAS#1392224-59-7

Theoretical Analysis

MedKoo Cat#: 562714

Name: myomiR-IN-1

CAS#: 1392224-59-7

Chemical Formula: C33H27NO6

Exact Mass: 533.1838

Molecular Weight: 533.58

Elemental Analysis: C, 74.28; H, 5.10; N, 2.63; O, 17.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
myomiR-IN-1; myomiR IN 1; myomiRIN1; myomiR inhibitor-1; myomiR inhibitor 1;
IUPAC/Chemical Name
8-(tert-Butylcarboxy)oxy-5-(8a-methoxy-3,8-dioxo-2-phenyl-2a,3,8,8a-tetrahydro-cyclobuta[b]naphthalen-1-yl)-quinoline
InChi Key
GNUJEUMWYJVRKO-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H27NO6/c1-32(2,3)40-31(37)39-24-17-16-20(21-15-10-18-34-28(21)24)26-25(19-11-6-5-7-12-19)27-29(35)22-13-8-9-14-23(22)30(36)33(26,27)38-4/h5-18,27H,1-4H3
SMILES Code
O=C(C1=C2C=CC=C1)C(C(C3=C4C=CC=NC4=C(OC(OC(C)(C)C)=O)C=C3)=C5C6=CC=CC=C6)(OC)C5C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 533.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Graham ZA, De Gasperi R, Bauman WA, Cardozo CP. Recombinant myostatin reduces highly expressed microRNAs in differentiating C2C12 cells. Biochem Biophys Rep. 2017 Mar;9:273-280. PubMed PMID: 28691106; PubMed Central PMCID: PMC5500170. 2: Tan SB, Li J, Chen X, Zhang W, Zhang D, Zhang C, Li D, Zhang Y. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway. Chem Biol. 2014 Oct 23;21(10):1265-1270. doi: 10.1016/j.chembiol.2014.06.011. Epub 2014 Sep 18. PubMed PMID: 25242288.