Synonym
TA-270; TA270; TA 270; LS-123351; LS123351; LS123351
IUPAC/Chemical Name
(E)-N-(4-hydroxy-1-methyl-3-(octyloxy)-2-oxo-1,2-dihydroquinolin-7-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)acrylamide
InChi Key
SZNJINHODJLULD-SDNWHVSQSA-N
InChi Code
InChI=1S/C29H36N2O7/c1-5-6-7-8-9-10-15-38-28-26(33)21-13-12-20(18-22(21)31(2)29(28)35)30-25(32)14-11-19-16-23(36-3)27(34)24(17-19)37-4/h11-14,16-18,33-34H,5-10,15H2,1-4H3,(H,30,32)/b14-11+
SMILES Code
O=C(NC1=CC2=C(C=C1)C(O)=C(OCCCCCCCC)C(N2C)=O)/C=C/C3=CC(OC)=C(O)C(OC)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
524.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mizutani N, Aoki Y, Nabe T, Ishiwara M, Yoshino S, Takagaki H, Kohno S. Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. Eur J Pharmacol. 2009 Jan 5;602(1):138-42. doi: 10.1016/j.ejphar.2008.11.006. PubMed PMID: 19022242.
2: Ishiwara M, Aoki Y, Takagaki H, Ui M, Okajima F. TA-270 [4-hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an anti-asthmatic agent, inhibits leukotriene production induced by IgE receptor stimulation in RBL-2H3 cells. J Pharmacol Exp Ther. 2003 Nov;307(2):583-8. PubMed PMID: 12970384.
3: Kimura N, Fukui H, Takagaki H, Yonemochi E, Terada K. Characterization of polymorphs of a novel quinolinone derivative, TA-270 (4-hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone). Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1321-5. PubMed PMID: 11605662.
4: Aoki Y, Ishiwara M, Koda A, Takagaki H. Inhibitory effect of a novel quinolinone derivative, TA-270, on asthmatic inflammatory responses in sensitized guinea pigs. Eur J Pharmacol. 2000 Dec 15;409(3):325-30. PubMed PMID: 11108828.
5: Kamat SK, Barde PJ, Raut SB. Evaluation of the estrogenic activity of Indian medicinal plants in immature rats. Anc Sci Life. 2015 Oct-Dec;35(2):90-5. doi: 10.4103/0257-7941.171669. PubMed PMID: 26865741; PubMed Central PMCID: PMC4728870.
6: Panteleon V, Kostakis IK, Marakos P, Pouli N, Andreadou I. Synthesis of some new spiropyranoquinolines and evaluation of their free radical scavenging activity. Chem Pharm Bull (Tokyo). 2009 May;57(5):446-52. PubMed PMID: 19420773.
