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MedKoo Cat#: 471062 | Name: GO289
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GO289 is a potent and selective CK2 inhibitor.

Chemical Structure

GO289
GO289
CAS#694522-87-7

Theoretical Analysis

MedKoo Cat#: 471062

Name: GO289

CAS#: 694522-87-7

Chemical Formula: C17H15BrN4O2S

Exact Mass: 418.0099

Molecular Weight: 419.33

Elemental Analysis: C, 48.70; H, 3.61; Br, 19.06; N, 13.36; O, 7.63; S, 7.65

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 Ready to ship
10mg USD 250.00 Ready to ship
25mg USD 550.00 Ready to ship
50mg USD 950.00 Ready to ship
100mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
GO289; GO 289; GO-289
IUPAC/Chemical Name
5-bromo-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol
InChi Key
DARDDBZKGVEVKB-VXLYETTFSA-N
InChi Code
InChI=1S/C17H15BrN4O2S/c1-24-15-8-12(13(18)9-14(15)23)10-19-22-16(20-21-17(22)25-2)11-6-4-3-5-7-11/h3-10,23H,1-2H3/b19-10+
SMILES Code
OC1=CC(Br)=C(/C=N/N2C(SC)=NN=C2C3=CC=CC=C3)C=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#A23M09B28
Safety Data Sheet (SDS)
View Safety
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 419.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Borgo C, Cesaro L, Hirota T, Kuwata K, D'Amore C, Ruppert T, Blatnik R, Salvi M, Pinna LA. Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach. Eur J Med Chem. 2021 Mar 15;214:113217. doi: 10.1016/j.ejmech.2021.113217. Epub 2021 Jan 27. PMID: 33548633. 2: Ogata A, Yamada T, Hattori S, Ikenuma H, Abe J, Tada M, Ichise M, Suzuki M, Ito K, Kato T, Amaike K, Hirota T, Kakita A, Itami K, Kimura Y. Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain. Bioorg Med Chem Lett. 2023 Jun 15;90:129327. doi: 10.1016/j.bmcl.2023.129327. Epub 2023 May 13. PMID: 37187253. 3: Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019 Jan 23;5(1):eaau9060. doi: 10.1126/sciadv.aau9060. PMID: 30746467; PMCID: PMC6357737. 4: Borgo C, D'Amore C, Cesaro L, Itami K, Hirota T, Salvi M, Pinna LA. A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability. Biochem Biophys Res Commun. 2020 Oct 20;531(3):409-415. doi: 10.1016/j.bbrc.2020.07.112. Epub 2020 Aug 14. PMID: 32800562.