FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer.
MedKoo Cat#: 406483
Name: FLI-06
CAS#: 313967-18-9
Chemical Formula: C25H30N2O5
Exact Mass: 438.2155
Molecular Weight: 438.52
Elemental Analysis: C, 68.47; H, 6.90; N, 6.39; O, 18.24
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.0 | 102.53 | |
| DMF | 20.0 | 45.61 | |
| DMF:PBS (pH 7.2) (1:4) | 0.2 | 0.46 | |
| Ethanol | 5.9 | 13.50 |
The following data is based on the product molecular weight 438.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
