Synonym
DN-108; DN108; DN 108;
IUPAC/Chemical Name
N-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenyl)-1-phenylcyclopropane-1-carboxamide
InChi Key
FTRMOJIRMFXZJV-UHFFFAOYSA-N
InChi Code
1S/C20H18N2O3S/c23-17-16(26-19(25)22-17)12-13-6-8-15(9-7-13)21-18(24)20(10-11-20)14-4-2-1-3-5-14/h1-9,16H,10-12H2,(H,21,24)(H,22,23,25)
SMILES Code
O=C(NC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3(CC3)C4=CC=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
366.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dabhi B, Mistry KN, Patel H, Lal S. Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy. Indian J Biochem Biophys. 2015 Apr;52(2):209-12. PMID: 26118134.
2: Ueda N, Nomura Y, Muta Y, Matsuzaki Y, Hayashibe M, Ino Y, Suzuki S, Kurumi M. Pharmacological and pharmacokinetic studies of the newly synthesized thiazolidinedione derivative 5-(4-(1-phenyl-1-cyclopropanecarbonylamino)benzyl)-thiazolidine-2 ,4-dio ne. Arzneimittelforschung. 1998 Jun;48(6):651-7. PMID: 9689422.
3: McKenna SA, Kim I, Puglisi EV, Lindhout DA, Aitken CE, Marshall RA, Puglisi JD. Purification and characterization of transcribed RNAs using gel filtration chromatography. Nat Protoc. 2007;2(12):3270-7. doi: 10.1038/nprot.2007.480. PMID: 18079727.
4: Amari S. [Bioinformatics from the point of view of neuroscience]. Tanpakushitsu Kakusan Koso. 2004 Jun;49(8):1226-30. Japanese. PMID: 15209218.
5: Hsu CW, Kuo CF, Chuang SM, Hou MH. Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex. Biometals. 2013 Feb;26(1):1-12. doi: 10.1007/s10534-012-9589-8. Epub 2012 Oct 25. PMID: 23097078.
6: Prass K, Ruscher K, Karsch M, Isaev N, Megow D, Priller J, Scharff A, Dirnagl U, Meisel A. Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab. 2002 May;22(5):520-5. doi: 10.1097/00004647-200205000-00003. PMID: 11973424.
7: Kanzawa F, Koizumi F, Koh Y, Nakamura T, Tatsumi Y, Fukumoto H, Saijo N, Yoshioka T, Nishio K. In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction. Clin Cancer Res. 2001 Jan;7(1):202-9. PMID: 11205910.
8: Hu P, Huang CZ, Li YF, Ling J, Liu YL, Fei LR, Xie JP. Magnetic particle- based sandwich sensor with DNA-modified carbon nanotubes as recognition elements for detection of DNA hybridization. Anal Chem. 2008 Mar 1;80(5):1819-23. doi: 10.1021/ac702187y. Epub 2008 Jan 31. PMID: 18232709.
