Synonym
Oxidopamine hydrochloride; Oxidopamine HCl; NSC233898; NSC-233898; NSC 233898; 6-OHDA
IUPAC/Chemical Name
2,4,5-Trihydroxyphenethylamine hydrochloride
InChi Key
QLMRJHFAGVFUAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
SMILES Code
NCCC1=CC(O)=C(O)C=C1O.[H]Cl
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
205.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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7: Varešlija D, Tipton KF, Davey GP, McDonald AG. 6-Hydroxydopamine: a far from simple neurotoxin. J Neural Transm (Vienna). 2020 Feb;127(2):213-230. doi: 10.1007/s00702-019-02133-6. Epub 2020 Jan 1. PMID: 31894418.
8: Hsu SW, Hsu PC, Chang WS, Yu CC, Wang YC, Yang JS, Tsai FJ, Chen KY, Tsai CW, Bau DT. Protective effects of valproic acid on 6-hydroxydopamine-induced neuroinjury. Environ Toxicol. 2020 Aug;35(8):840-848. doi: 10.1002/tox.22920. Epub 2020 Mar 13. PMID: 32167238.
9: Cauli O, Morelli M. Caffeine and the dopaminergic system. Behav Pharmacol. 2005 Mar;16(2):63-77. doi: 10.1097/00008877-200503000-00001. PMID: 15767841.
10: Barilar JO, Knezovic A, Perhoc AB, Homolak J, Riederer P, Salkovic-Petrisic M. Shared cerebral metabolic pathology in non-transgenic animal models of Alzheimer's and Parkinson's disease. J Neural Transm (Vienna). 2020 Feb;127(2):231-250. doi: 10.1007/s00702-020-02152-8. Epub 2020 Feb 6. PMID: 32030485; PMCID: PMC7035309.
