Synonym
Oxidopamine Free Base; CCRIS4342; CCRIS-4342; CCRIS 4342; 6-Hydroxydopamine
IUPAC/Chemical Name
5-(2-aminoethyl)benzene-1,2,4-triol
InChi Key
DIVDFFZHCJEHGG-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2
SMILES Code
NCCc1c(O)cc(O)c(O)c1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
169.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pantic I, Cumic J, Skodric SR, Dugalic S, Brodski C. Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology. Chem Biol Interact. 2021 Feb 25;336:109380. doi: 10.1016/j.cbi.2021.109380. Epub 2021 Jan 13. PMID: 33450287.
2: Simola N, Morelli M, Carta AR. The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res. 2007 Apr;11(3-4):151-67. doi: 10.1007/BF03033565. PMID: 17449457.
3: Hernandez-Baltazar D, Zavala-Flores LM, Villanueva-Olivo A. The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model. Neurologia. 2017 Oct;32(8):533-539. English, Spanish. doi: 10.1016/j.nrl.2015.06.011. Epub 2015 Aug 21. PMID: 26304655.
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6: Bouchatta O, Manouze H, Bouali-Benazzouz R, Kerekes N, Ba-M'hamed S, Fossat P, Landry M, Bennis M. Neonatal 6-OHDA lesion model in mouse induces Attention- Deficit/ Hyperactivity Disorder (ADHD)-like behaviour. Sci Rep. 2018 Oct 18;8(1):15349. doi: 10.1038/s41598-018-33778-0. PMID: 30337626; PMCID: PMC6193955.
7: Varešlija D, Tipton KF, Davey GP, McDonald AG. 6-Hydroxydopamine: a far from simple neurotoxin. J Neural Transm (Vienna). 2020 Feb;127(2):213-230. doi: 10.1007/s00702-019-02133-6. Epub 2020 Jan 1. PMID: 31894418.
8: Hsu SW, Hsu PC, Chang WS, Yu CC, Wang YC, Yang JS, Tsai FJ, Chen KY, Tsai CW, Bau DT. Protective effects of valproic acid on 6-hydroxydopamine-induced neuroinjury. Environ Toxicol. 2020 Aug;35(8):840-848. doi: 10.1002/tox.22920. Epub 2020 Mar 13. PMID: 32167238.
9: Cauli O, Morelli M. Caffeine and the dopaminergic system. Behav Pharmacol. 2005 Mar;16(2):63-77. doi: 10.1097/00008877-200503000-00001. PMID: 15767841.
10: Barilar JO, Knezovic A, Perhoc AB, Homolak J, Riederer P, Salkovic-Petrisic M. Shared cerebral metabolic pathology in non-transgenic animal models of Alzheimer's and Parkinson's disease. J Neural Transm (Vienna). 2020 Feb;127(2):231-250. doi: 10.1007/s00702-020-02152-8. Epub 2020 Feb 6. PMID: 32030485; PMCID: PMC7035309.
