Butacaine sulfate | CAS#149-15-5 | white crystalline ester

MedKoo Cat#: 591782 | Name: Butacaine sulfate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Butacaine sulfate, a white crystalline ester, is applied to mucous membranes as a local anesthetic.

Chemical Structure

Butacaine sulfate

CAS#149-15-5 (sulfate)

Theoretical Analysis

MedKoo Cat#: 591782

Name: Butacaine sulfate

CAS#: 149-15-5 (sulfate)

Chemical Formula: C36H62N4O8S

Exact Mass: 0.0000

Molecular Weight: 710.97

Elemental Analysis: C, 60.82; H, 8.79; N, 7.88; O, 18.00; S, 4.51

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 350.00	2 Weeks
1g	USD 650.00	2 Weeks

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Related CAS #

5892-15-9 (chloride) 149-15-5 (sulfate)

Synonym

Butacaine sulfate; Butyn; AI3-02405; AI3 02405; AI302405

IUPAC/Chemical Name

1-Propanol, 3-(dibutylamino)-, 4-aminobenzoate (ester), sulfate (2:1) (salt)

InChi Key

VWZAGCZUPZKTET-UHFFFAOYSA-N

InChi Code

InChI=1S/2C18H30N2O2.H2O4S/c2*1-3-5-12-20(13-6-4-2)14-7-15-22-18(21)16-8-10-17(19)11-9-16;1-5(2,3)4/h2*8-11H,3-7,12-15,19H2,1-2H3;(H2,1,2,3,4)

SMILES Code

CCCCN(CCCOC(C1=CC=C(N)C=C1)=O)CCCC.CCCCN(CCCOC(C2=CC=C(N)C=C2)=O)CCCC.O=S(O)(O)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 710.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shimomura T, Irie K, Fujiyoshi Y. Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics. FEBS J. 2016 Aug;283(15):2881-95. doi: 10.1111/febs.13776. Epub 2016 Jul 14. PubMed PMID: 27273848. 2: Avdeef A, Kansy M, Bendels S, Tsinman K. Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis. Eur J Pharm Sci. 2008 Jan;33(1):29-41. Epub 2007 Oct 2. PubMed PMID: 17983735. 3: Avdeef A, Bendels S, Tsinman O, Tsinman K, Kansy M. Solubility-excipient classification gradient maps. Pharm Res. 2007 Mar;24(3):530-45. PubMed PMID: 17245653. 4: Bendels S, Tsinman O, Wagner B, Lipp D, Parrilla I, Kansy M, Avdeef A. PAMPA - excipient classification gradient map. Pharm Res. 2006 Nov;23(11):2525-35. Epub 2006 Oct 20. PubMed PMID: 17053953. 5: Lu DP. Managing patients with local anesthetic complications using alternative methods. Pa Dent J (Harrisb). 2002 May-Jun;69(3):22-9. PubMed PMID: 12174527. 6: Kristal BS, Conway AD, Brown AM, Jain JC, Ulluci PA, Li SW, Burke WJ. Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. Free Radic Biol Med. 2001 Apr 15;30(8):924-31. PubMed PMID: 11295535. 7: Shin S, Kim YB, Hur GH. Involvement of phospholipase A2 activation in anthrax lethal toxin-induced cytotoxicity. Cell Biol Toxicol. 1999 Feb;15(1):19-29. PubMed PMID: 10195347. 8: Cassarino DS, Parks JK, Parker WD Jr, Bennett JP Jr. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta. 1999 Jan 6;1453(1):49-62. PubMed PMID: 9989245. 9: Lai PM, Roberts MS. Epidermal iontophoresis: II. Application of the ionic mobility-pore model to the transport of local anesthetics. Pharm Res. 1998 Oct;15(10):1579-88. PubMed PMID: 9794501. 10: Kristal BS, Dubinsky JM. Mitochondrial permeability transition in the central nervous system: induction by calcium cycling-dependent and -independent pathways. J Neurochem. 1997 Aug;69(2):524-38. PubMed PMID: 9231710. 11: Weinberg JM, Roeser NF, Davis JA, Venkatachalam MA. Glycine-protected, hypoxic, proximal tubules develop severely compromised energetic function. Kidney Int. 1997 Jul;52(1):140-51. PubMed PMID: 9211356. 12: Heo J, Kim GH, Lee KS, Go WU, Ju HJ, Park SK, Song CS, Song GA, Cho M, Yang US, Moon HK, Kim YK. Effect of Ca2+ channel blockers, external Ca2+ and phospholipase A2 inhibitors on t-butylhydroperoxide-induced lipid peroxidation and toxicity in rat liver slices. Korean J Intern Med. 1997 Jun;12(2):193-200. PubMed PMID: 9439155; PubMed Central PMCID: PMC4531990. 13: Lambert C, Erdmann A, Eikmanns M, Kramer R. Triggering Glutamate Excretion in Corynebacterium glutamicum by Modulating the Membrane State with Local Anesthetics and Osmotic Gradients. Appl Environ Microbiol. 1995 Dec;61(12):4334-42. PubMed PMID: 16535186; PubMed Central PMCID: PMC1388651. 14: Campo R, Brullet E, Montserrat A, Calvet X, Rivero E, Brotons C. Topical pharyngeal anesthesia improves tolerance of upper gastrointestinal endoscopy: a randomized double-blind study. Endoscopy. 1995 Nov;27(9):659-64. PubMed PMID: 8903978. 15: Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem. 1993 Jul 5;268(19):13791-8. PubMed PMID: 8314748. 16: Bridal TR, Busath D. Inhibition of gramicidin channel activity by local anesthetics. Biochim Biophys Acta. 1992 Jun 11;1107(1):31-8. PubMed PMID: 1377493. 17: Jung DW, Davis MH, Brierley GP. Estimation of matrix pH in isolated heart mitochondria using a fluorescent probe. Anal Biochem. 1989 May 1;178(2):348-54. PubMed PMID: 2751096. 18: Guimaraes CR, Rodrigues LA, Vettore O, Antonio A. The relaxing response of the isolated rat duodenum to nicotine. Gen Pharmacol. 1988;19(5):655-9. PubMed PMID: 3215477. 19: Attwood D, Fletcher P. Self-association of local anaesthetic drugs in aqueous solution. J Pharm Pharmacol. 1986 Jul;38(7):494-8. PubMed PMID: 2875147. 20: Koehler KA, Hines J, Mansour EG, Rustum YM, Jahagirdar DV, Jain MK. Comparison of the membrane-related effects of cytarabine and other agents on model membranes. Biochem Pharmacol. 1985 Nov 15;34(22):4025-31. PubMed PMID: 4062974.