Hydroxysafflor yellow A | CAS#78281-02-4 | anti-inflammatory

MedKoo Cat#: 461695 | Name: Hydroxysafflor yellow A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxysafflor yellow A is an active ingredient in Carthamus tinctorius L. that has anti-inflammatory and anti-fibrosis properties.

Chemical Structure

Hydroxysafflor yellow A

CAS#78281-02-4

Theoretical Analysis

MedKoo Cat#: 461695

Name: Hydroxysafflor yellow A

CAS#: 78281-02-4

Chemical Formula: C27H32O16

Exact Mass: 612.1690

Molecular Weight: 612.53

Elemental Analysis: C, 52.94; H, 5.27; O, 41.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Hydroxysafflor yellow A; Safflomin A;

IUPAC/Chemical Name

3,4,5-trihydroxy-2-((E)-3-(4-hydroxyphenyl)acryloyl)-4-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)cyclohexa-2,5-dien-1-one

InChi Key

LIPJRCGLQNIXGO-ONZBGLOFSA-N

InChi Code

InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1

SMILES Code

O=C1C([C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)=C(O)C(O)([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(O)=C1C(/C=C/C4=CC=C(O)C=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 612.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xu RA, Xu ZS, Ge RS. Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats. J Ethnopharmacol. 2014 Feb 12;151(3):1141-1146. doi: 10.1016/j.jep.2013.12.025. Epub 2013 Dec 27. PubMed PMID: 24373810. 2: Wang Y, Xue C, Dong F, Peng Y, Zhang Y, Jin M, Zang B, Tan L. Hydroxysafflor yellow a attenuates small airway remodeling in a rat model of chronic obstructive pulmonary disease. Biol Pharm Bull. 2014;37(10):1591-8. Epub 2014 Jul 24. PubMed PMID: 25056232. 3: Ma GN, Yu FL, Wang S, Li ZP, Xie XY, Mei XG. A novel oral preparation of hydroxysafflor yellow A base on a chitosan complex: a strategy to enhance the oral bioavailability. AAPS PharmSciTech. 2015 Jun;16(3):675-82. doi: 10.1208/s12249-014-0255-z. Epub 2014 Dec 16. PubMed PMID: 25511808; PubMed Central PMCID: PMC4444637. 4: Liu YL, Liu YJ, Liu Y, Li XS, Liu SH, Pan YG, Zhang J, Liu Q, Hao YY. Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways. Int Immunopharmacol. 2014 Dec;23(2):649-57. PubMed PMID: 25466274. 5: Jiang S, Shi Z, Li C, Ma C, Bai X, Wang C. Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2595-608. eCollection 2014. PubMed PMID: 24966974; PubMed Central PMCID: PMC4069906. 6: Wang T, Duan SJ, Wang SY, Lu Y, Zhu Q, Wang LJ, Han B. Coadministration of hydroxysafflor yellow A with levodopa attenuates the dyskinesia. Physiol Behav. 2015 Aug 1;147:193-7. doi: 10.1016/j.physbeh.2015.04.038. Epub 2015 Apr 23. PubMed PMID: 25914172. 7: Zhu HJ, Wang LJ, Wang XQ, Pan H, Li NS, Yang HB, Jin M, Zang BX, Gong FY. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Oct;67(5):885-92. doi: 10.1007/s10616-014-9783-3. Epub 2015 Mar 7. PubMed PMID: 25749912; PubMed Central PMCID: PMC4545440. 8: Wang J, Zhang Q, Mei X, Zhang X. Hydroxysafflor yellow A attenuates left ventricular remodeling after pressure overload-induced cardiac hypertrophy in rats. Pharm Biol. 2014 Jan;52(1):31-5. doi: 10.3109/13880209.2013.805791. Epub 2013 Sep 13. PubMed PMID: 24033225. 9: Li CY, Yin JG, Zhang J, Wang XX, Xu MJ, Liu F, Zou JD, Ju WZ. Pharmacokinetic profiles of hydroxysafflor yellow A following intravenous administration of its pure preparations in healthy Chinese volunteers. J Ethnopharmacol. 2015 Mar 13;162:225-30. doi: 10.1016/j.jep.2014.12.068. Epub 2015 Jan 7. PubMed PMID: 25576896. 10: Li CY, Chu JH, Zhang J, Sun BT, Dai GL, Liu SJ, Ju WZ. Measurement of hydroxysafflor yellow A in human urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:131-7. doi: 10.1016/j.jchromb.2014.10.036. Epub 2014 Nov 4. PubMed PMID: 25463208. 11: He Y, Liu Q, Li Y, Yang X, Wang W, Li T, Zhang W, Cui Y, Wang C, Lin R. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78. doi: 10.1007/s13105-015-0382-3. Epub 2015 Jan 28. PubMed PMID: 25626885. 12: Liu Q, Wang CY, Liu Z, Ma XS, He YH, Chen SS, Bai XY. Hydroxysafflor yellow A suppresses liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling. Pharm Biol. 2014 Sep;52(9):1085-93. doi: 10.3109/13880209.2013.877491. Epub 2014 Mar 12. PubMed PMID: 24618007. 13: Yang G, Zhou X, Chen T, Deng Y, Yu D, Pan S, Song Y. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302. eCollection 2015. PubMed PMID: 26131104; PubMed Central PMCID: PMC4483943. 14: Yang F, Li J, Zhu J, Wang D, Chen S, Bai X. Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-κB signaling pathway in H22 tumor-bearing mice. Eur J Pharmacol. 2015 May 5;754:105-14. doi: 10.1016/j.ejphar.2015.02.015. Epub 2015 Feb 24. PubMed PMID: 25720342. 15: Zhu HJ, Wang LJ, Wang XQ, Pan H, Li NS, Yang HB, Jin M, Zang BX, Gong FY. Hormone-sensitive lipase is involved in the action of hydroxysafflor yellow A (HYSA) inhibiting adipogenesis of 3T3-L1cells. Fitoterapia. 2014 Mar;93:182-8. doi: 10.1016/j.fitote.2014.01.001. Epub 2014 Jan 17. PubMed PMID: 24440907. 16: Lv Y, Qian Y, Fu L, Chen X, Zhong H, Wei X. Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway. Eur J Pharmacol. 2015 Dec 15;769:324-32. doi: 10.1016/j.ejphar.2015.11.036. Epub 2015 Nov 25. PubMed PMID: 26607471. 17: Song Y, Long L, Zhang N, Liu Y. Inhibitory effects of hydroxysafflor yellow A on PDGF BB induced proliferation and migration of vascular smooth muscle cells via mediating Akt signaling. Mol Med Rep. 2014 Sep;10(3):1555-60. doi: 10.3892/mmr.2014.2336. Epub 2014 Jun 16. PubMed PMID: 24939805. 18: Wang C, Wang C, Ma C, Huang Q, Sun H, Zhang X, Bai X. Hydroxysafflor yellow A of Carthamus tinctorius attenuates lung injury of aged rats exposed to gasoline engine exhaust by down-regulating platelet activation. Phytomedicine. 2014 Feb 15;21(3):199-206. doi: 10.1016/j.phymed.2013.09.018. Epub 2013 Nov 2. PubMed PMID: 24192212. 19: Guo Y, Wang Y, Huang X, Lv H, Fan R, Huang W, Gan P, Liu W, Yan K, Xia Z, Liu J. Determination of hydroxysafflor yellow A in biological fluids of patients with traumatic brain injury by UPLC-ESI-MS/MS after injection of Xuebijing. Biomed Chromatogr. 2014 Aug;28(8):1090-5. doi: 10.1002/bmc.3124. Epub 2014 Feb 17. PubMed PMID: 24535782. 20: Jingshan Z, Qianyu G, Shaohong L, Shangyue Z, Hongli H. [Hydroxysafflor yellow A inhibits rat vascular smooth muscle cells proliferation possibly via blocking signal transduction of MEK-ERK1/2]. Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Aug;43(8):728-31. Chinese. PubMed PMID: 26955733.