Synonym
Orgotein; Ontosein; Palosein
IUPAC/Chemical Name
tetracopper;tetrazinc
InChi Key
TUGDLVFMIQZYPA-UHFFFAOYSA-N
InChi Code
InChI=1S/4Cu.4Zn/q8*+2
SMILES Code
[Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
515.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Edsmyr F, Menander-Huber KB. Orgotein efficacy in ameliorating side effects due to radiation therapy. Eur J Rheumatol Inflamm. 1981;4(2):228-36. PMID: 7044789.
2: Goebel KM, Storck U, Neurath F. Intrasynovial orgotein therapy in rheumatoid arthritis. Lancet. 1981 May 9;1(8228):1015-7. doi: 10.1016/s0140-6736(81)92185-1. PMID: 6112411.
3: Esco R, Valencia J, Coronel P, Carceller JA, Gimeno M, Bascón N. Efficacy of orgotein in prevention of late side effects of pelvic irradiation: a randomized study. Int J Radiat Oncol Biol Phys. 2004 Nov 15;60(4):1211-9. doi: 10.1016/j.ijrobp.2004.04.038. PMID: 15519794.
4: Goebel KM, Storck U. Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees. Am J Med. 1983 Jan;74(1):124-8. doi: 10.1016/0002-9343(83)91128-2. PMID: 6336891.
5: Escribano A, García-Grande A, Montañés P, Miralles L, García A. Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: a feasibility study. Neoplasma. 2002;49(3):201-8. PMID: 12098008.
6: Cividalli A, Adami M, De Tomasi F, Palmisano L, Pardini MC, Spanò M, Mauro F. Orgotein as a radioprotector in normal tissues. Experiments on mouse skin and a murine adenocarcinoma. Acta Radiol Oncol. 1985 May-Jun;24(3):273-7. doi: 10.3109/02841868509134400. PMID: 2994380.
7: Gammer W, Brobäck LG. Clinical comparison of orgotein and methylprednisolone acetate in the treatment of osteoarthrosis of the knee joint. Scand J Rheumatol. 1984;13(2):108-12. doi: 10.3109/03009748409100372. PMID: 6377491.
8: Huber W. Orgotein--(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology. Eur J Rheumatol Inflamm. 1981;4(2):173-82. PMID: 7343319.
9: Menander-Huber KB, Edsmyr F, Huber W. Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo- controlled study in patients with bladder tumours. Urol Res. 1978;6(4):255-7. doi: 10.1007/BF00262630. PMID: 105443.
10: Cushing LS, Decker WE, Santos FK, Schulte TL, Huber W. Orgotein therapy for inflammation in horses. Mod Vet Pract. 1973 Jul;54(7):17-21. PMID: 4736630.
