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MedKoo Cat#: 564853 | Name: IMD-0560
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IMD-0560 is an IKK inhibitor which suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration.

Chemical Structure

IMD-0560
IMD-0560
CAS#439144-66-8

Theoretical Analysis

MedKoo Cat#: 564853

Name: IMD-0560

CAS#: 439144-66-8

Chemical Formula: C15H8BrF6NO2

Exact Mass: 426.9643

Molecular Weight: 428.13

Elemental Analysis: C, 42.08; H, 1.88; Br, 18.66; F, 26.63; N, 3.27; O, 7.47

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
IMD0560; IMD 0560; IMD-0560
IUPAC/Chemical Name
N-[2,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide
InChi Key
SVGRIJCSKWXOPA-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H8BrF6NO2/c16-8-2-4-12(24)9(6-8)13(25)23-11-5-7(14(17,18)19)1-3-10(11)15(20,21)22/h1-6,24H,(H,23,25)
SMILES Code
O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sawada I, Hashimoto K, Sawada K, Kinose Y, Nakamura K, Toda A, Nakatsuka E, Yoshimura A, Mabuchi S, Fujikawa T, Itai A, Kimura T. The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice. Int J Gynecol Cancer. 2016 May;26(4):610-8. doi: 10.1097/IGC.0000000000000668. PubMed PMID: 26905334. 2: Toda A, Sawada K, Fujikawa T, Wakabayashi A, Nakamura K, Sawada I, Yoshimura A, Nakatsuka E, Kinose Y, Hashimoto K, Mabuchi S, Tokuhira A, Nakayama M, Itai A, Kurachi H, Kimura T. Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells. Am J Pathol. 2016 Mar;186(3):616-29. doi: 10.1016/j.ajpath.2015.11.004. Epub 2016 Jan 12. PubMed PMID: 26796146. 3: Tada Y, Kokabu S, Sugiyama G, Nakatomi C, Aoki K, Fukushima H, Osawa K, Sugamori Y, Ohya K, Okamoto M, Fujikawa T, Itai A, Matsuo K, Watanabe S, Jimi E. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30. PubMed PMID: 25373602; PubMed Central PMCID: PMC4322973. 4: Orita S, Miyagi M, Kobori S, Gemba T, Ishikawa T, Inoue G, Toyone T, Aoki Y, Eguchi Y, Takahashi K, Ohtori S. IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats. Spine J. 2013 Mar;13(3):284-8. doi: 10.1016/j.spinee.2013.01.020. Epub 2013 Feb 23. PubMed PMID: 23462514. 5: Wakatsuki S, Suzuki J, Ogawa M, Masumura M, Muto S, Shimizu T, Takayama K, Itai A, Isobe M. A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration. Expert Opin Ther Targets. 2008 Dec;12(12):1469-76. doi: 10.1517/14728220802551140 . PubMed PMID: 19007316. 6: Okazaki Y, Sawada T, Nagatani K, Komagata Y, Inoue T, Muto S, Itai A, Yamamoto K. Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis. J Rheumatol. 2005 Aug;32(8):1440-7. PubMed PMID: 16078317.