CV-4-26 | TEAD inhibitor

MedKoo Cat#: 127828 | Name: CV-4-26

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CV-4-26 is an TEAD inhibitor as Potential Antiliver Cancer Agent. CV-4-26 exhibited great antitumor activity in HCC and HB cell lines in vitro, xenografted human HCC, and murine HB in vivo. These outcomes signify the potential of a highly promising therapeutic candidate for addressing a subset of HCC and HB cancers

Chemical Structure

CV-4-26

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127828

Name: CV-4-26

CAS#: N/A

Chemical Formula: C18H12Cl2F3NO2

Exact Mass: 401.0197

Molecular Weight: 402.19

Elemental Analysis: C, 53.75; H, 3.01; Cl, 17.63; F, 14.17; N, 3.48; O, 7.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CV-4-26; CV 4-26; CV4-26

IUPAC/Chemical Name

2-chloro-1-(6-chloro-5-((3-(trifluoromethyl)benzyl)oxy)-1H-indol-3-yl)ethan-1-one

InChi Key

XWEKXBSPGJHXNK-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H12Cl2F3NO2/c19-7-16(25)13-8-24-15-6-14(20)17(5-12(13)15)26-9-10-2-1-3-11(4-10)18(21,22)23/h1-6,8,24H,7,9H2

SMILES Code

ClCC(C1=CNC2=C1C=C(OCC3=CC=CC(C(F)(F)F)=C3)C(Cl)=C2)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 402.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Zhou C, Sun C, Zhou W, Tian T, Schultz DC, Wu T, Yu M, Wu L, Pi L, Li C. Development of Novel Indole-Based Covalent Inhibitors of TEAD as Potential Antiliver Cancer Agents. J Med Chem. 2024 Sep 13. doi: 10.1021/acs.jmedchem.4c00925. Epub ahead of print. PMID: 39270302.