MedKoo Cat#: 463671 | Name: 4-HQN
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4-HQN is a potent PARP-1 inhibitor and heterocyclic building block. It has been used in the synthesis of compounds with antimalarial or antimicrobial activities in vitro.

Chemical Structure

4-HQN
4-HQN
CAS#491-36-1

Theoretical Analysis

MedKoo Cat#: 463671

Name: 4-HQN

CAS#: 491-36-1

Chemical Formula: C8H6N2O

Exact Mass: 146.0480

Molecular Weight: 146.15

Elemental Analysis: C, 65.75; H, 4.14; N, 19.17; O, 10.95

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
4-HQN; 4HQN; 4 HQN; 4-Hydroxyquinazoline; 4 Hydroxyquinazoline;
IUPAC/Chemical Name
quinazolin-4(1H)-one
InChi Key
QMNUDYFKZYBWQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
SMILES Code
O=C1N=CNC2=C1C=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 146.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Sumegi B. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther. 2004 Jul;310(1):247-55. doi: 10.1124/jpet.104.065151. Epub 2004 Mar 3. PMID: 14999056.