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MedKoo Cat#: 510213 | Name: Tea Polyphenol (TP98)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. These chemical compounds are believed to be beneficial to human health, and they are the basis of many claims made about the health benefits of tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number of other health problems. The compounds found in tea have also been linked with cancer reduction.

Chemical Structure

Tea Polyphenol (TP98)
Tea Polyphenol (TP98)
CAS#84650-60-2 (Tea polyphenol)

Theoretical Analysis

MedKoo Cat#: 510213

Name: Tea Polyphenol (TP98)

CAS#: 84650-60-2 (Tea polyphenol)

Chemical Formula:

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis:

Price and Availability

Size Price Availability Quantity
5g USD 150.00 Ready to ship
10g USD 250.00 Ready to ship
50g USD 550.00 Ready to ship
100g USD 950.00 Ready to ship
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Related CAS #
84650-60-2 (Tea polyphenol) 84650-60-2 (green tea extract)
Synonym
TP98, TP-98; TP 98; Tea Polyphenol; 98% Tea Polyphenol; Green tea extract.
IUPAC/Chemical Name
Tea polyphenol, flavanoids and tannins, green tea extract.
InChi Key
N/A
InChi Code
N/A
SMILES Code
N/A
Appearance
Light yellow to light pink solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The composition of the tea leaves depends on a variety of factors, including climate, season, horticultural practices, and the type and age of the plant. The chemical composition of green tea is similar to that of the leaf. Green tea contains polyphenolic compounds, which include flavanols, flavandiols, flavonoids, and phenolic acids and account for 30% of the dry weight of green tea leaves. Most of the polyphenols in green tea are flavanols, commonly known as catechins; the major catechins in green tea are (2)-epicatechin, (2)-epicatechin-3-gallate, (2)-epigallocatechin, and (2)-epigallocatechin-3-gallate (EGCG). In black teas, the major polyphenols are theaflavin and thearubigin.     Major chemical compositions in tea polyphenol: (-)-epicatechin (EC):  (2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol (-)-epicatechin-3-gallate (ECG): (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate (-)-epigallocatechin (EGC): (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol (-)-epigallocatechin-3-gallate (EGCG): (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate    
Product Data
Product Data
Certificate of Analysis
View CoA: current batch, Lot#B7B12C21
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction
Biological target:
Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism.
In vitro activity:
Treatment with EGCG (the most bioactive polyphenol in green tea) for 24 h resulted in the inhibition of cell proliferation in a dose-dependent manner. As shown in Figure 1, EGCG inhibited the growth of SW480, SW620, and LS411N cells with an IC50 of 74.6, 99.4, and 112.1 μg/mL at 24 h, respectively. Besides, the results showed that SW480 cells were more sensitive to EGCG than SW620 and LS411N cells (Figure 1). Reference: Gastroenterol Rep (Oxf). 2021 Jan; 9(1): 59–70. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962736/
In vivo activity:
MRI examination showed that TP (tea polyphenol) treatment improved disc degeneration. Although rats in the saline degeneration group maintained the original height of the intervertebral space in the first week, the disc signal significantly decreased; however, TP-treated rats showed a high disc signal level in the first week. Although the signal was somewhat indistinct and dispersed compared to the signal observed in the control group, the overall situation was better than that of the degeneration group (saline). In the MRIs performed at the second and fourth weeks, it was observed that the discs in the degeneration group became “dark discs” with an obvious decreased height of the intervertebral space. Conversely, the discs in the TP group showed an obvious improvement and retained high signals; the signal of the disc did not go dark sharply, although the height of the intervertebral space continued to decrease. Reference: Oxid Med Cell Longev. 2021; 2021: 6684147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811431/

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Luo KW, Xia J, Cheng BH, Gao HC, Fu LW, Luo XL. Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3. Gastroenterol Rep (Oxf). 2020 Dec 3;9(1):59-70. doi: 10.1093/gastro/goaa072. PMID: 33747527; PMCID: PMC7962736. 2. Jang M, Park R, Park YI, Cha YE, Yamamoto A, Lee JI, Park J. EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro. Biochem Biophys Res Commun. 2021 Apr 2;547:23-28. doi: 10.1016/j.bbrc.2021.02.016. Epub 2021 Feb 10. PMID: 33588235; PMCID: PMC7874949. 3. Song D, Ge J, Wang Y, Yan Q, Wu C, Yu H, Yang M, Yang H, Zou J. Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway. Oxid Med Cell Longev. 2021 Jan 7;2021:6684147. doi: 10.1155/2021/6684147. PMID: 33505586; PMCID: PMC7811431. 4. Li Z, Chang L, Ren X, Hu Y, Chen Z. Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol. ACS Omega. 2021 Jan 7;6(2):1725-1731. doi: 10.1021/acsomega.0c05903. PMID: 33490831; PMCID: PMC7818641.
In vitro protocol:
1. Luo KW, Xia J, Cheng BH, Gao HC, Fu LW, Luo XL. Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3. Gastroenterol Rep (Oxf). 2020 Dec 3;9(1):59-70. doi: 10.1093/gastro/goaa072. PMID: 33747527; PMCID: PMC7962736. 2. Jang M, Park R, Park YI, Cha YE, Yamamoto A, Lee JI, Park J. EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro. Biochem Biophys Res Commun. 2021 Apr 2;547:23-28. doi: 10.1016/j.bbrc.2021.02.016. Epub 2021 Feb 10. PMID: 33588235; PMCID: PMC7874949.
In vivo protocol:
1. Song D, Ge J, Wang Y, Yan Q, Wu C, Yu H, Yang M, Yang H, Zou J. Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway. Oxid Med Cell Longev. 2021 Jan 7;2021:6684147. doi: 10.1155/2021/6684147. PMID: 33505586; PMCID: PMC7811431. 2. Li Z, Chang L, Ren X, Hu Y, Chen Z. Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol. ACS Omega. 2021 Jan 7;6(2):1725-1731. doi: 10.1021/acsomega.0c05903. PMID: 33490831; PMCID: PMC7818641.
1: Baladia E, Basulto J, Manera M, Martínez R, Calbet D. [Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis]. Nutr Hosp. 2014 Mar 1;29(3):479-90. doi: 10.3305/nh.2014.29.3.7118. Review. Spanish. PubMed PMID: 24558988. 2: Wang X, Tian J, Jiang J, Li L, Ying X, Tian H, Nie M. Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. J Hum Nutr Diet. 2014 Oct;27(5):501-12. doi: 10.1111/jhn.12181. Epub 2013 Nov 8. Review. PubMed PMID: 24206044. 3: Li G, Zhang Y, Thabane L, Mbuagbaw L, Liu A, Levine MA, Holbrook A. Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis. J Hypertens. 2015 Feb;33(2):243-54. doi: 10.1097/HJH.0000000000000426. Review. PubMed PMID: 25479028. 4: Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Eur J Nutr. 2014 Sep;53(6):1299-311. doi: 10.1007/s00394-014-0720-1. Epub 2014 May 27. Review. PubMed PMID: 24861099. 5: Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013 Mar 1;4(2):129-40. doi: 10.3945/an.112.003269. Review. PubMed PMID: 23493529; PubMed Central PMCID: PMC3649093. 6: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Primary cancer prevention by green tea, and tertiary cancer prevention by the combination of green tea catechins and anticancer compounds. J Cancer Prev. 2015 Mar;20(1):1-4. doi: 10.15430/JCP.2015.20.1.1. Review. PubMed PMID: 25853098; PubMed Central PMCID: PMC4384709. 7: Jówko E. Green Tea Catechins and Sport Performance. In: Lamprecht M, editor. Antioxidants in Sport Nutrition. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 8. PubMed PMID: 26065095. 8: Yiannakopoulou ECh. Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies. Eur J Cancer Prev. 2014 Mar;23(2):84-9. doi: 10.1097/CEJ.0b013e328364f23e. Review. PubMed PMID: 23939462. 9: Fritz H, Seely D, Kennedy DA, Fernandes R, Cooley K, Fergusson D. Green tea and lung cancer: a systematic review. Integr Cancer Ther. 2013 Jan;12(1):7-24. doi: 10.1177/1534735412442378. Epub 2012 Apr 24. Review. PubMed PMID: 22532034. 10: Teschke R, Zhang L, Melzer L, Schulze J, Eickhoff A. Green tea extract and the risk of drug-induced liver injury. Expert Opin Drug Metab Toxicol. 2014 Dec;10(12):1663-76. doi: 10.1517/17425255.2014.971011. Epub 2014 Oct 15. Review. PubMed PMID: 25316200. 11: Suganuma M, Takahashi A, Watanabe T, Iida K, Matsuzaki T, Yoshikawa HY, Fujiki H. Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins. Molecules. 2016 Nov 18;21(11). pii: E1566. Review. PubMed PMID: 27869750. 12: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds. J Cancer Res Clin Oncol. 2015 Sep;141(9):1511-22. doi: 10.1007/s00432-014-1899-5. Epub 2014 Dec 28. Review. PubMed PMID: 25544670. 13: Pazyar N, Feily A, Kazerouni A. Green tea in dermatology. Skinmed. 2012 Nov-Dec;10(6):352-5. Review. PubMed PMID: 23346663. 14: Albassam AA, Markowitz JS. An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis). Planta Med. 2017 Apr;83(6):496-508. doi: 10.1055/s-0043-100934. Epub 2017 Jan 24. Review. PubMed PMID: 28118673. 15: Ramshankar V, Krishnamurthy A. Chemoprevention of oral cancer: Green tea experience. J Nat Sci Biol Med. 2014 Jan;5(1):3-7. doi: 10.4103/0976-9668.127272. Review. PubMed PMID: 24678188; PubMed Central PMCID: PMC3961947. 16: Fujiki H, Imai K, Nakachi K, Shimizu M, Moriwaki H, Suganuma M. Challenging the effectiveness of green tea in primary and tertiary cancer prevention. J Cancer Res Clin Oncol. 2012 Aug;138(8):1259-70. doi: 10.1007/s00432-012-1250-y. Epub 2012 Jun 15. Review. PubMed PMID: 22699930. 17: Yang CS, Pan E. The effects of green tea polyphenols on drug metabolism. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):677-89. doi: 10.1517/17425255.2012.681375. Epub 2012 Apr 18. Review. PubMed PMID: 22509899. 18: Li G, Zhang Y, Mbuagbaw L, Holbrook A, Levine MA, Thabane L. Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review. BMJ Open. 2014 Apr 17;4(4):e004971. doi: 10.1136/bmjopen-2014-004971. Review. PubMed PMID: 24742977; PubMed Central PMCID: PMC3996813. 19: Suganuma M, Saha A, Fujiki H. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci. 2011 Feb;102(2):317-23. doi: 10.1111/j.1349-7006.2010.01805.x. Epub 2010 Dec 30. Review. PubMed PMID: 21199169. 20: Yuan JM. Green tea and prevention of esophageal and lung cancers. Mol Nutr Food Res. 2011 Jun;55(6):886-904. doi: 10.1002/mnfr.201000637. Epub 2011 Apr 29. Review. PubMed PMID: 21538848; PubMed Central PMCID: PMC3400335.