ARN24092 | CAS#unknown | NKCC1 Inhibitor

MedKoo Cat#: 464858 | Name: ARN24092

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARN24092 is a NKCC1 Inhibitor for the Treatment of Core Symptoms in Down Syndrome.

Chemical Structure

ARN24092

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464858

Name: ARN24092

CAS#: unknown

Chemical Formula: C17H25F3N2O5S

Exact Mass: 426.1436

Molecular Weight: 426.45

Elemental Analysis: C, 47.88; H, 5.91; F, 13.37; N, 6.57; O, 18.76; S, 7.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ARN24092; ARN 24092; ARN-24092;

IUPAC/Chemical Name

5-(N,N-dimethylsulfamoyl)-2-hydroxy-4-((8,8,8-trifluorooctyl)amino)benzoic acid

InChi Key

ZVTDZLUHVSFIEB-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H25F3N2O5S/c1-22(2)28(26,27)15-10-12(16(24)25)14(23)11-13(15)21-9-7-5-3-4-6-8-17(18,19)20/h10-11,21,23H,3-9H2,1-2H3,(H,24,25)

SMILES Code

O=C(O)C1=CC(S(=O)(N(C)C)=O)=C(NCCCCCCCC(F)(F)F)C=C1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 426.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Borgogno M, Savardi A, Manigrasso J, Turci A, Portioli C, Ottonello G, Bertozzi SM, Armirotti A, Contestabile A, Cancedda L, De Vivo M. Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome. J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00603. Epub ahead of print. PMID: 34137257.