Synonym
Chlorproethazine hydrochloride; Chlorproethazine HCl; 4909RP; 4909-RP; 4909 RP; NSC169470; NSC-169470; NSC 169470
IUPAC/Chemical Name
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-diethyl-, monohydrochloride (9CI)
InChi Key
XXQMDKCWUYZXOF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23ClN2S.ClH/c1-3-21(4-2)12-7-13-22-16-8-5-6-9-18(16)23-19-11-10-15(20)14-17(19)22;/h5-6,8-11,14H,3-4,7,12-13H2,1-2H3;1H
SMILES Code
CCN(CC)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Matthews WB. The action of chlorproethazine on spasticity. Brain. 1965 Dec;88(5):1057-64. doi: 10.1093/brain/88.5.1057. PMID: 5324919.
2: Cariou C, Droitcourt C, Osmont MN, Marguery MC, Dutartre H, Delaunay J, Avenel-Audran M, Dupuy A, Adamski H. Photodermatitis from topical phenothiazines: A case series. Contact Dermatitis. 2020 Jul;83(1):19-24. doi: 10.1111/cod.13509. Epub 2020 Mar 25. PMID: 32124458.
3: Kerr A, Woods J, Ferguson J. Photocontact allergic and phototoxic studies of chlorproethazine. Photodermatol Photoimmunol Photomed. 2008 Feb;24(1):11-5. doi: 10.1111/j.1600-0781.2008.00324.x. PMID: 18201351.
4: Barbaud A, Collet E, Martin S, Granel F, Trechot P, Lambert D, Schmutz JL. Contact sensitization to chlorproethazine can induce persistent light reaction and cross-photoreactions to other phenothiazines. Contact Dermatitis. 2001 Jun;44(6):373. doi: 10.1034/j.1600-0536.2001.440609-8.x. PMID: 11417527.
5: Loesche C, Dejobert Y, Thomas P. Immediate wheal after topical administration of chlorproethazine. Contact Dermatitis. 1992 Apr;26(4):278. doi: 10.1111/j.1600-0536.1992.tb00256.x. PMID: 1395581.
6: SIGWALD J, BOUTTIER D, RAYMONDEAUD C. [Chlorproethazine. Its importance in neurology]. Presse Med. 1961 Nov 18;69:2187-9. French. PMID: 13912756.
7: FOLLIN S, AZOULAY J, ARNULF G, BEROUTIR, SEMPE JC. [Chlorproethazine. Its value in psychiatry]. Presse Med. 1962 Oct 13;70:1982-4. French. PMID: 13958556.
8: Girre C, Koch H, Crouzette J, Palombo S, Fournier PE. Gas chromatographic determination of chlorproethazine in plasma. J Chromatogr. 1987 Aug 7;419:363-7. doi: 10.1016/0378-4347(87)80301-8. PMID: 3667792.
9: MEIDINGER F. [Experimental decontracturant action of chlorproethazine]. C R Seances Soc Biol Fil. 1962;156:477-81. French. PMID: 14472161.
10: Jeanmougin M, Sigal-Nahum M, Manciet JR, Petit A, Flageul B, Dubertret L. Photosensibilisation rémanente induite par la chlorproéthazine [Retentive photosensitivity induced by chlorproethazine]. Ann Dermatol Venereol. 1993;120(11):840-3. French. PMID: 8210139.
