Chlorproethazine | CAS# 84-01-5 | muscle relaxant or tranquilizer

MedKoo Cat#: 413170 | Name: Chlorproethazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorproethazine sold under the brand name Neuriplege, is a drug of the phenothiazine group described as a muscle relaxant or tranquilizer which is or has been marketed in Europe as a topical cream for the treatment of muscle pain. It has been associated with photoallergic contact dermatitis.

Chemical Structure

Chlorproethazine

CAS#84-01-5 (free base)

Theoretical Analysis

MedKoo Cat#: 413170

Name: Chlorproethazine

CAS#: 84-01-5 (free base)

Chemical Formula: C19H23ClN2S

Exact Mass: 346.1270

Molecular Weight: 346.92

Elemental Analysis: C, 65.78; H, 6.68; Cl, 10.22; N, 8.08; S, 9.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

4611-02-3 (HCl) 84-01-5 (free base)

Synonym

Chlorproethazine; Neuriplege; RP4909; RP-4909; RP 4909

IUPAC/Chemical Name

10H-Phenothiazine-10-propanamine, 2-chloro-N,N-diethyl- (9CI)

InChi Key

DBOUGBAQLIXZLV-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H23ClN2S/c1-3-21(4-2)12-7-13-22-16-8-5-6-9-18(16)23-19-11-10-15(20)14-17(19)22/h5-6,8-11,14H,3-4,7,12-13H2,1-2H3

SMILES Code

CCN(CC)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Matthews WB. The action of chlorproethazine on spasticity. Brain. 1965 Dec;88(5):1057-64. doi: 10.1093/brain/88.5.1057. PMID: 5324919. 2: Cariou C, Droitcourt C, Osmont MN, Marguery MC, Dutartre H, Delaunay J, Avenel-Audran M, Dupuy A, Adamski H. Photodermatitis from topical phenothiazines: A case series. Contact Dermatitis. 2020 Jul;83(1):19-24. doi: 10.1111/cod.13509. Epub 2020 Mar 25. PMID: 32124458. 3: Kerr A, Woods J, Ferguson J. Photocontact allergic and phototoxic studies of chlorproethazine. Photodermatol Photoimmunol Photomed. 2008 Feb;24(1):11-5. doi: 10.1111/j.1600-0781.2008.00324.x. PMID: 18201351. 4: Barbaud A, Collet E, Martin S, Granel F, Trechot P, Lambert D, Schmutz JL. Contact sensitization to chlorproethazine can induce persistent light reaction and cross-photoreactions to other phenothiazines. Contact Dermatitis. 2001 Jun;44(6):373. doi: 10.1034/j.1600-0536.2001.440609-8.x. PMID: 11417527. 5: Loesche C, Dejobert Y, Thomas P. Immediate wheal after topical administration of chlorproethazine. Contact Dermatitis. 1992 Apr;26(4):278. doi: 10.1111/j.1600-0536.1992.tb00256.x. PMID: 1395581. 6: SIGWALD J, BOUTTIER D, RAYMONDEAUD C. [Chlorproethazine. Its importance in neurology]. Presse Med. 1961 Nov 18;69:2187-9. French. PMID: 13912756. 7: FOLLIN S, AZOULAY J, ARNULF G, BEROUTIR, SEMPE JC. [Chlorproethazine. Its value in psychiatry]. Presse Med. 1962 Oct 13;70:1982-4. French. PMID: 13958556. 8: Girre C, Koch H, Crouzette J, Palombo S, Fournier PE. Gas chromatographic determination of chlorproethazine in plasma. J Chromatogr. 1987 Aug 7;419:363-7. doi: 10.1016/0378-4347(87)80301-8. PMID: 3667792. 9: MEIDINGER F. [Experimental decontracturant action of chlorproethazine]. C R Seances Soc Biol Fil. 1962;156:477-81. French. PMID: 14472161. 10: Jeanmougin M, Sigal-Nahum M, Manciet JR, Petit A, Flageul B, Dubertret L. Photosensibilisation rémanente induite par la chlorproéthazine [Retentive photosensitivity induced by chlorproethazine]. Ann Dermatol Venereol. 1993;120(11):840-3. French. PMID: 8210139.