MIF098 | macrophage migration inhibitory factor | MIF antagonist | CAS#1208448-95-6

MedKoo Cat#: 127956 | Name: MIF098

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.

Chemical Structure

MIF098

CAS#1208448-95-6

Theoretical Analysis

MedKoo Cat#: 127956

Name: MIF098

CAS#: 1208448-95-6

Chemical Formula: C15H13NO3

Exact Mass: 255.0895

Molecular Weight: 255.27

Elemental Analysis: C, 70.58; H, 5.13; N, 5.49; O, 18.80

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
1g	USD 4,850.00	2 Weeks

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Related CAS #

No Data

Synonym

MIF098; MIF-098; MIF 098

IUPAC/Chemical Name

3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one

InChi Key

JJXKGUBHEQGADG-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H13NO3/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3

SMILES Code

O=C1OC2=CC=C(C)C=C2N1CC3=CC=CC(O)=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 255.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol. 2019 Nov;76:105874. doi: 10.1016/j.intimp.2019.105874. Epub 2019 Sep 6. PMID: 31499270. 2: Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL, Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM, Bogue M, Miller RA. 17-a-estradiol late in life extends lifespan in aging UM- HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell. 2021 May;20(5):e13328. doi: 10.1111/acel.13328. Epub 2021 Mar 31. Erratum in: Aging Cell. 2022 Nov;21(11):e13672. doi: 10.1111/acel.13672. PMID: 33788371; PMCID: PMC8135004. 3: Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy S, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome. Arthritis Rheumatol. 2019 Jan;71(1):109-120. doi: 10.1002/art.40672. Epub 2018 Dec 4. PMID: 30009530; PMCID: PMC6310104. 4: Poulsen KL, McMullen MR, Huang E, Kibler CD, Sheehan MM, Leng L, Bucala R, Nagy LE. Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice. Alcohol Clin Exp Res. 2019 Jul;43(7):1439-1451. doi: 10.1111/acer.14065. Epub 2019 May 14. PMID: 31009094; PMCID: PMC6602811. 5: Ma F, Hunt DE, Leng L, Bucala R, Meyer-Siegler KL, Vera PL. Protease activated-receptor 4 activation as a model of persistent bladder pain: Essential role of macrophage migration inhibitory factor and high mobility group box 1. Int J Urol. 2018 Oct;25(10):887-893. doi: 10.1111/iju.13778. Epub 2018 Aug 15. PMID: 30112848; PMCID: PMC6436093.