TαMCA-d4 | CAS#unknown | TαMCA quantification standard

MedKoo Cat#: 464801 | Name: TαMCA-d4 sodium salt

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tauro-α-muricholic acid-d4 (TαMCA-d4) is intended for use as an internal standard for the quantification of TαMCA by GC- or LC-MS. TαMCA is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid. TαMCA is common in rodents but has also been found in small amounts in human serum.

Chemical Structure

TαMCA-d4 sodium salt

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464801

Name: TαMCA-d4 sodium salt

CAS#: unknown

Chemical Formula: C26H40D4NNaO7S

Exact Mass: 541.2987

Molecular Weight: 541.71

Elemental Analysis: C, 57.65; H, 8.93; N, 2.59; Na, 4.24; O, 20.67; S, 5.92

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 850.00	2 Weeks

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Related CAS #

No Data

Synonym

TαMCA-d4; TαMCA d4; Tauro-α-muricholate-d4; Tauro-α-muricholic Acid-d4 (sodium salt);

IUPAC/Chemical Name

sodium 2-((R)-4-((3R,5R,6S,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl-2,2,4,4-d4)pentanamido)ethane-1-sulfonate

InChi Key

NYXROOLWUZIWRB-YHXAEYHASA-M

InChi Code

InChI=1S/C26H45NO7S.Na/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31;/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34);/q;+1/p-1/t15-,16-,17-,18+,19+,20+,22+,23+,24+,25-,26-;/m1./s1/i8D2,14D2;

SMILES Code

C[C@@H]([C@]1(CC[C@]2([C@@]3([C@@H]([C@H]([C@@]4(C([2H])([C@@H](C([2H])(C[C@@]4([C@]3(CC[C@@]21C)[H])C)[2H])O)[2H])[H])O)O)[H])[H])[H])CCC(NCCS([O-])(=O)=O)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	18.46
	DMSO	10.0	18.46
	DMSO:PBS (pH 7.2) (1:4)	0.2	0.37
	Ethanol	1.0	1.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 541.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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