PSMA-1092 | CAS#2481214-35-9 | PSMA binding motif probe

MedKoo Cat#: 464775 | Name: PSMA1092

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSMA-1092 is a novel probe bearing two prostate specific membrane antigen (PSMA) binding motifs. PSMA1092 displays excellent optical properties (λmax = 1092 nm) and ultrahigh affinity (Ki = 80 pM) toward PSMA. The tumor was visualized with high resolution (tissue-to-normal tissue ratio = 7.62 ± 1.05) and clear margin by NIR-II imaging using PSMA-1092 in a mouse model. During the tumor resection, residual tumors missed by visible.

Chemical Structure

PSMA1092

CAS#2481214-35-9

Theoretical Analysis

MedKoo Cat#: 464775

Name: PSMA1092

CAS#: 2481214-35-9

Chemical Formula: C50H62N12O16S2

Exact Mass: 1150.3848

Molecular Weight: 1151.23

Elemental Analysis: C, 52.17; H, 5.43; N, 14.60; O, 22.24; S, 5.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2481214-35-9

Synonym

PSMA-1092; PSMA1092; PSMA 1092;

IUPAC/Chemical Name

N/A

InChi Key

BJKPHQIRJVRGKT-TYBYDDOHSA-N

InChi Code

InChI=1S/C50H62N12O16S2/c1-61(25-21-35(63)51-23-5-3-7-31(45(69)70)53-49(77)55-33(47(73)74)17-19-37(65)66)29-13-9-27(10-14-29)39-41-43(59-79-57-41)40(44-42(39)58-80-60-44)28-11-15-30(16-12-28)62(2)26-22-36(64)52-24-6-4-8-32(46(71)72)54-50(78)56-34(48(75)76)18-20-38(67)68/h9-16,31-34H,3-8,17-26H2,1-2H3,(H,51,63)(H,52,64)(H,65,66)(H,67,68)(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H2,53,55,77)(H2,54,56,78)/t31?,32?,33-,34-/m0/s1

SMILES Code

CN(CCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)C(C=C1)=CC=C1C2=C(N=S=N3)C3=C(C4=CC=C(N(CCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)C)C=C4)C5=NSN=C52

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,151.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang L, Shi X, Li Y, Duan X, Zhang Z, Fu H, Yang X, Tian J, Hu Z, Cui M. Visualizing Tumors in Real Time: A Highly Sensitive PSMA Probe for NIR-II Imaging and Intraoperative Tumor Resection. J Med Chem. 2021 Jun 10;64(11):7735-7745. doi: 10.1021/acs.jmedchem.1c00444. Epub 2021 May 28. PMID: 34047189.