Resomelagon, also known as AP1189, is a melanocortin receptor agonist, specifically MC1 and MC3. Resomelagon is also an active oral anti-inflammatory and resolution-promoting compound. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold.
MedKoo Cat#: 124404
Name: Resomelagon mesylate
CAS#: 2933183-20-9 (mesylate)
Chemical Formula: C15H18N6O5S
Exact Mass: 0.0000
Molecular Weight: 394.41
Elemental Analysis: C, 45.68; H, 4.60; N, 21.31; O, 20.28; S, 8.13
The following data is based on the product molecular weight 394.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
