FR 901537 | CAS#161162-21-6 | aromatase inhibitor

MedKoo Cat#: 525104 | Name: FR 901537

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR 901537 is a new aromatase inhibitor. FR 901537 has antitumor effects. FR901537 is a promising drug in the treatment of estrogen-dependent mammary tumors in postmenopausal women.

Chemical Structure

FR 901537

CAS#161162-21-6

Theoretical Analysis

MedKoo Cat#: 525104

Name: FR 901537

CAS#: 161162-21-6

Chemical Formula: C23H29N3O6S2

Exact Mass: 507.1498

Molecular Weight: 507.62

Elemental Analysis: C, 54.42; H, 5.76; N, 8.28; O, 18.91; S, 12.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FR 901537; FR-901537; FR901537;

IUPAC/Chemical Name

Butanamide, N-(3-((2-((2,3-dihydro-6-hydroxy-2-oxo-1H-naphtho(2,1-b)(1,4)thiazin-5-yl)thio)ethyl)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethyl-, (R)-

InChi Key

HKEFKAJRMICMPZ-NRFANRHFSA-N

InChi Code

InChI=1S/C23H29N3O6S2/c1-23(2,12-27)21(31)22(32)25-8-7-15(28)24-9-10-33-20-18(30)14-6-4-3-5-13(14)17-19(20)34-11-16(29)26-17/h3-6,21,27,30-31H,7-12H2,1-2H3,(H,24,28)(H,25,32)(H,26,29)/t21-/m0/s1

SMILES Code

O=C1Nc2c(SC1)c(SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO)O)c(O)c1ccccc21

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 507.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Oohata N, Kawamura I, Lacey E, Nishigaki F, Matsumoto S, Tsujimoto S, Naoe Y, Manda T, Shimomura K. A new aromatase inhibitor, FR901537. II. Pharmacological and antitumor effects. J Antibiot (Tokyo). 1995 Aug;48(8):763-7. PubMed PMID: 7592018. 2: Oohata N, Hori Y, Yamagishi Y, Fujita T, Takase S, Yamashita M, Terano H, Okuhara M. A new aromatase inhibitor, FR901537. I. Taxonomy, fermentation, isolation, physiochemical characteristics and biological activities. J Antibiot (Tokyo). 1995 Aug;48(8):757-62. PubMed PMID: 7592017.