KDT-501 Free Base | CAS# 1374228-86-0 (free base) | type 2 diabetes

MedKoo Cat#: 414222 | Name: KDT-501 Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KDT-501 Free Base is in phase II clinical trials by KinDex Therapeutics for the treatment of type 2 diabetes. It is also in preclinical trials for the treatment of polycystic ovarian syndrome (POS), non-alcoholic fatty liver disease (NAFLD).

Chemical Structure

KDT-501 Free Base

CAS#1374228-86-0 (free base)

Theoretical Analysis

MedKoo Cat#: 414222

Name: KDT-501 Free Base

CAS#: 1374228-86-0 (free base)

Chemical Formula: C21H33KO5

Exact Mass: 404.1965

Molecular Weight: 404.59

Elemental Analysis: C, 62.34; H, 8.22; K, 9.66; O, 19.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1374228-86-0 (free base) 1374259-84-3 (potassium)

Synonym

KDT-501 Free Base; KDT501 Free Base; KDT 501 Free Base

IUPAC/Chemical Name

potassium (1R,5S)-2-hydroxy-5-isopentyl-3-(3-methylbutanoyl)-1-(4-methylpentanoyl)-4-oxocyclopent-2-en-1-olate

InChi Key

OBRIOHODJVKWGS-WSZABJOTSA-N

InChi Code

InChI=1S/C21H33O5.K/c1-12(2)7-9-15-19(24)18(16(22)11-14(5)6)20(25)21(15,26)17(23)10-8-13(3)4;/h12-15,25H,7-11H2,1-6H3;/q-1;+1/t15-,21+;/m1./s1

SMILES Code

CC(CC[C@@H]1C(C(C(CC(C)C)=O)=C([C@]1(C(CCC(C)C)=O)[O-])O)=O)C.[K+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 404.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Konda VR, Desai A, Darland G, Grayson N, Bland JS. KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes. PLoS One. 2014 Jan 30;9(1):e87848. doi: 10.1371/journal.pone.0087848. PubMed PMID: 24498211; PubMed Central PMCID: PMC3907559.