MedKoo Cat#: 463472 | Name: PW0787
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PW0787 is an orally bioavailable, brain-penetrant, potent, and selective GPR52 agonist. PW0787 dose-dependently suppresses amphetamine-evoked hyperactivity, suggesting a therapeutic potential for neuropsychiatric diseases. PW0787 increases the frequency and number of evoked action potentials in D2, but not D1, medium spiny neurons of the nucleus accumbens.

Chemical Structure

PW0787
PW0787
CAS#2624131-45-7

Theoretical Analysis

MedKoo Cat#: 463472

Name: PW0787

CAS#: 2624131-45-7

Chemical Formula: C23H20F4N4O2

Exact Mass: 460.1522

Molecular Weight: 460.43

Elemental Analysis: C, 60.00; H, 4.38; F, 16.50; N, 12.17; O, 6.95

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,350.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 6,250.00 2 Weeks
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Related CAS #
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Synonym
PW0787; PW 0787; PW-0787;
IUPAC/Chemical Name
1-(6-(3-fluoro-5-(trifluoromethyl)benzyl)pyrimidin-4-yl)-N-(2-hydroxyethyl)indoline-4-carboxamide
InChi Key
OLNVWBLTVAPNME-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H20F4N4O2/c24-16-9-14(8-15(11-16)23(25,26)27)10-17-12-21(30-13-29-17)31-6-4-18-19(2-1-3-20(18)31)22(33)28-5-7-32/h1-3,8-9,11-13,32H,4-7,10H2,(H,28,33)
SMILES Code
O=C(C1=CC=CC2=C1CCN2C3=NC=NC(CC4=CC(C(F)(F)F)=CC(F)=C4)=C3)NCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Murphy, R. M., Chen, H., Zhou, J., & Allen, J. A. (2024). Extracellular Loop 2-Dependent Mechanism of Action for Orphan Receptor GPR52 Allosteric Agonists. 2: Murphy, R. E., Felsing, D. E., Dvorak, N. M., Laezza, F., Cunningham, K. A., & Allen, J. A. (2023). Discovery of an Allosteric Agonist for Schizophrenia Risk Gene GPR52 with Antipsychotic Activity. 3: Felsing, D., Wang, P., Murphy, R., Zhou, J., & Allen, J. (2021). Structure Activity Relationships of Novel GPR52 Agonists that Suppress Psychostimulant Behavior. The FASEB Journal, 35. 4: Torramade, E., Bofill, X., Cole, P., & Fernandez-Forner, D. (2021). NME Digest-April 2021. Drugs of the Future, 46(4).