Imigliptin Free Base | CAS# 1314944-07-4 (free base) | dipeptidyl peptidase IV inhibitor

MedKoo Cat#: 414214 | Name: Imigliptin Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imigliptin Free Base is a dipeptidyl peptidase IV inhibitor; antidiabetic activity.

Chemical Structure

Imigliptin Free Base

CAS#1314944-07-4 (free base)

Theoretical Analysis

MedKoo Cat#: 414214

Name: Imigliptin Free Base

CAS#: 1314944-07-4 (free base)

Chemical Formula: C21H24N6O

Exact Mass: 376.2012

Molecular Weight: 376.46

Elemental Analysis: C, 67.00; H, 6.43; N, 22.32; O, 4.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1314944-07-4 (free base) 1314944-07-4 (2HCl)

Synonym

Imigliptin Free Base; KBP3853; KBP 3853; KBP-3853

IUPAC/Chemical Name

2-((7-((3R)-3-Amino-1-piperidinyl)-2,3-dihydro-3,5-dimethyl-2-oxo-1H-imidazo(4,5-b)pyridin-1-yl)methyl)benzonitrile

InChi Key

UWSKGQJKQNVRJZ-QGZVFWFLSA-N

InChi Code

InChI=1S/C21H24N6O/c1-14-10-18(26-9-5-8-17(23)13-26)19-20(24-14)25(2)21(28)27(19)12-16-7-4-3-6-15(16)11-22/h3-4,6-7,10,17H,5,8-9,12-13,23H2,1-2H3/t17-/m1/s1

SMILES Code

N#CC1=CC=CC=C1CN(C2=C(N3C[C@H](N)CCC3)C=C(C)N=C2N4C)C4=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 376.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shu C, Ge H, Song M, Chen JH, Zhou H, Qi Q, Wang F, Ma X, Yang X, Zhang G, Ding Y, Zhou D, Peng P, Shih CK, Xu J, Wu F. Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. doi: 10.1021/ml5001905. PMID: 25147615; PMCID: PMC4137375. 2: Liu Y, Song L, Yao X, Wu Y, Liu H, Zhao Q, Jiang J, Shi C, Ma X, Zhou H, Liu D, Hu P. A high-performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of imigliptin, its five metabolites and alogliptin in human plasma and urine and its application to a multiple-dose pharmacokinetic study. Biomed Chromatogr. 2018 Nov;32(11):e4324. doi: 10.1002/bmc.4324. Epub 2018 Aug 7. PMID: 29952007. 3: Liu D, Ma X, Liu Y, Zhou H, Shi C, Wu F, Jiang J, Hu P. Quantitative prediction of human pharmacokinetics and pharmacodynamics of imigliptin, a novel DPP-4 inhibitor, using allometric scaling, IVIVE and PK/PD modeling methods. Eur J Pharm Sci. 2016 Jun 30;89:73-82. doi: 10.1016/j.ejps.2016.04.020. Epub 2016 Apr 21. PMID: 27108678. 4: Liu Y, Liu D, Liu H, Song H, Song L, Yao X, Wu F, Shu C, Ma X, Zhou H, Jiang J, Hu P. Simultaneous determination of imigliptin and its three metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:300-12. doi: 10.1016/j.jchromb.2015.08.003. Epub 2015 Aug 20. PMID: 26355270. 5: Liu Y, Yao X, Song L, Liu H, Zhao Q, Jiang J, Ni G, Shi C, Ma X, Zhou H, Liu D, Hu P. Metabolites characterization of a novel DPP-4 inhibitor, imigliptin in humans and rats using ultra-high performance liquid chromatography coupled with synapt high-resolution mass spectrometry. J Pharm Biomed Anal. 2018 Aug 5;157:189-200. doi: 10.1016/j.jpba.2018.05.029. Epub 2018 May 23. PMID: 29803910.