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MedKoo Cat#: 577968 | Name: NAS-181 methanesulfonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.

Chemical Structure

NAS-181 methanesulfonate
NAS-181 methanesulfonate
CAS#205242-62-2

Theoretical Analysis

MedKoo Cat#: 577968

Name: NAS-181 methanesulfonate

CAS#: 205242-62-2

Chemical Formula: C20H30N2O7S

Exact Mass: 442.1774

Molecular Weight: 442.53

Elemental Analysis: C, 54.28; H, 6.83; N, 6.33; O, 25.31; S, 7.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NAS-181 methanesulfonate; NAS 181 methanesulfonate; NAS181 methanesulfonate
IUPAC/Chemical Name
Morpholine, 2-(((3-(4-morpholinylmethyl)-2H-1-benzopyran-8-yl)oxy)methyl)-, (2R)-, methanesulfonate (1:1)
InChi Key
JDFGAOJLDPTWBF-UNTBIKODSA-N
InChi Code
1S/C19H26N2O4.CH4O3S/c1-2-16-10-15(12-21-5-8-22-9-6-21)13-25-19(16)18(3-1)24-14-17-11-20-4-7-23-17;1-5(2,3)4/h1-3,10,17,20H,4-9,11-14H2;1H3,(H,2,3,4)/t17-;/m1./s1
SMILES Code
CS(=O)(=O)O.C(Oc1cccc2C=C(CN3CCOCC3)COc12)[C@H]4CNCCO4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. de Groote L, Klompmakers AA, Olivier B, Westenberg HG. An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex. Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):89-94. doi: 10.1007/s00210-002-0685-0. Epub 2003 Jan 24. PMID: 12595948. 2. Stenfors C, Yu H, Ross SB. Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain. Neuropharmacology. 2000 Feb 14;39(4):553-60. doi: 10.1016/s0028-3908(99)00173-2. PMID: 10728876. 3. Hu XJ, Wang FH, Stenfors C, Ogren SO, Kehr J. Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: a microdialysis study. Eur Neuropsychopharmacol. 2007 Sep;17(9):580-6. doi: 10.1016/j.euroneuro.2006.12.002. Epub 2007 Jan 16. PMID: 17234388.

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