Synonym
Imigliptin Dihydrochloride; Imigliptin
IUPAC/Chemical Name
(R)-2-((7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)methyl)benzonitrile dihydrochloride
InChi Key
TYFRVIKMTJPQNF-ZEECNFPPSA-N
InChi Code
InChI=1S/C21H24N6O.2ClH/c1-14-10-18(26-9-5-8-17(23)13-26)19-20(24-14)25(2)21(28)27(19)12-16-7-4-3-6-15(16)11-22;;/h3-4,6-7,10,17H,5,8-9,12-13,23H2,1-2H3;2*1H/t17-;;/m1../s1
SMILES Code
N#CC1=CC=CC=C1CN(C2=C(N3C[C@H](N)CCC3)C=C(C)N=C2N4C)C4=O.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
449.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu D, Ma X, Liu Y, Zhou H, Shi C, Wu F, Jiang J, Hu P. Quantitative prediction of human pharmacokinetics and pharmacodynamics of imigliptin, a novel DPP-4 inhibitor, using allometric scaling, IVIVE and PK/PD modeling methods. Eur J Pharm Sci. 2016 Jun 30;89:73-82. doi: 10.1016/j.ejps.2016.04.020. Epub 2016 Apr 21. PubMed PMID: 27108678.
2: Liu Y, Liu D, Liu H, Song H, Song L, Yao X, Wu F, Shu C, Ma X, Zhou H, Jiang J, Hu P. Simultaneous determination of imigliptin and its three metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:300-12. doi: 10.1016/j.jchromb.2015.08.003. PubMed PMID: 26355270.
3: Shu C, Ge H, Song M, Chen JH, Zhou H, Qi Q, Wang F, Ma X, Yang X, Zhang G, Ding Y, Zhou D, Peng P, Shih CK, Xu J, Wu F. Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. doi: 10.1021/ml5001905. PubMed PMID: 25147615; PubMed Central PMCID: PMC4137375.
