Aclarubicin, an anthracycline antibiotic, exhibits potent anti-tumor activity in vitro by intercalating into DNA and inhibiting topoisomerase I and II, leading to DNA damage and apoptosis. Studies have shown that aclarubicin effectively inhibits proliferation in various cancer cell lines, including leukemia, breast, and lung cancer, with IC₅₀ values typically in the nanomolar to low micromolar range. Unlike doxorubicin, aclarubicin demonstrates reduced cardiotoxicity and less propensity to induce drug resistance. Additionally, it disrupts transcription by interfering with RNA polymerase II, contributing to its cytotoxic effects. Combination studies suggest synergistic effects with other chemotherapeutics, enhancing apoptosis and DNA damage responses in resistant tumor models.
MedKoo Cat#: 576901
Name: Aclarubicin free base
CAS#: 57576-44-0 (free base)
Chemical Formula: C42H53NO15
Exact Mass: 811.3415
Molecular Weight: 811.88
Elemental Analysis: C, 62.14; H, 6.58; N, 1.73; O, 29.56
The following data is based on the product molecular weight 811.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
