Nacartocin | CAS#77727-10-7 | Oxytocin Analog

MedKoo Cat#: 111526 | Name: Nacartocin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nacartocin is an analog of oxytocin that is almost 3 times more potent as a natriuretic agent.

Chemical Structure

Nacartocin

CAS#77727-10-7

Theoretical Analysis

MedKoo Cat#: 111526

Name: Nacartocin

CAS#: 77727-10-7

Chemical Formula: C46H71N11O11S

Exact Mass: 985.5100

Molecular Weight: 986.20

Elemental Analysis: C, 56.02; H, 7.26; N, 15.62; O, 17.85; S, 3.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

50-56-6 (analog oxytocin)

Synonym

IUPAC/Chemical Name

(S)-1-((4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((S)-sec-butyl)-16-(4-ethylbenzyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide

InChi Key

JPYLEKXLHLKVBI-IHJZLXGESA-N

InChi Code

InChI=1S/C46H71N11O11S/c1-6-26(5)39-45(67)52-29(14-15-35(47)58)41(63)54-33(23-36(48)59)42(64)53-30(16-19-69-20-17-38(61)51-32(43(65)56-39)22-28-12-10-27(7-2)11-13-28)46(68)57-18-8-9-34(57)44(66)55-31(21-25(3)4)40(62)50-24-37(49)60/h10-13,25-26,29-34,39H,6-9,14-24H2,1-5H3,(H2,47,58)(H2,48,59)(H2,49,60)(H,50,62)(H,51,61)(H,52,67)(H,53,64)(H,54,63)(H,55,66)(H,56,65)/t26-,29-,30-,31-,32-,33-,34-,39-/m0/s1

SMILES Code

CC[C@@H]([C@@H]1NC([C@@H](NC(CCSCC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CC(C)C)=O)=O)NC([C@@H](NC([C@@H](NC1=O)CCC(N)=O)=O)CC(N)=O)=O)=O)Cc3ccc(CC)cc3)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 986.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Machová A, Schreiber V. The natriuretic effect of 1-24 ACTH in rats: a comparison with the natriuretic oxytocin analogue nacartocin. Physiol Bohemoslov. 1986;35(1):90-3. PMID: 3010351. 2: Gersl V, Hajzlerová K, Troppová V. The effects of nacartocin and oxytocin on the cardiovascular system of rabbits in vivo. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1985;28(3-5):165-80. PMID: 3870447. 3: Skopková J, Barth T, Hrbas P, Jost K, Lebel M. Natriuretic properties of [2-p-ethylphenylalanine] deamino-6-carba-oxytocin (Nacartocin) in cats. Exp Clin Endocrinol. 1984 Oct;84(2):235-8. doi: 10.1055/s-0029-1210393. PMID: 6543187. 4: Brest'ák M, Barth T, Rotta L, Servítová L, Jost K, Fuchs V. Nové úcinné inhibitory oxytocinu v testu na prouzku lidské dĕlohy in vitro [Effective new oxytocin inhibitors in tests on strips of the human uterus in vitro]. Cesk Gynekol. 1984 Jul;49(6):404-7. Czech. PMID: 6488334. 5: Hrbas P, Skopková J, Zicha J, Barth T, Lebl M, Jost K. Nacartocin--analogue of oxytocin with enhanced natriuretic properties: natriuretic and hemodynamic characteristics. Endocrinol Exp. 1984 Jun;18(2):117-24. PMID: 6611251.