Tryptamine-d4 HCl | CAS#340257-60-5 | Tryptamine quantification internal standard

MedKoo Cat#: 464156 | Name: Tryptamine-d4 HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tryptamine-d4 is intended for use as an internal standard for the quantification of tryptamine by GC- or LC-MS. Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants. It increases levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus. Tryptamine is also a product of tryptophan metabolism in mammals. Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.

Chemical Structure

Tryptamine-d4 HCl

CAS#340257-60-5

Theoretical Analysis

MedKoo Cat#: 464156

Name: Tryptamine-d4 HCl

CAS#: 340257-60-5

Chemical Formula: C10H9D4ClN2

Exact Mass:

Molecular Weight: 200.70

Elemental Analysis: C, 59.84; H, 8.53; Cl, 17.66; N, 13.96

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 275.00	2 Weeks
5mg	USD 650.00	2 Weeks

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Related CAS #

No Data

Synonym

Tryptamine-d4 HCl; Tryptamine d4 HCl;

IUPAC/Chemical Name

2-(1H-indol-3-yl)ethan-1,1,2,2-d4-1-amine hydrochloride

InChi Key

KDFBGNBTTMPNIG-NXMSQKFDSA-N

InChi Code

InChI=1S/C10H12N2.ClH/c11-6-5-8-7-12-10-4-2-1-3-9(8)10;/h1-4,7,12H,5-6,11H2;1H/i5D2,6D2;

SMILES Code

NC([2H])(C([2H])(C1=CNC2=CC=CC=C12)[2H])[2H].Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 200.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Asakawa D, Mizuno H, Sugiyama E, Todoroki K. Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis. Analyst. 2021 Feb 23. doi: 10.1039/d0an02069a. Epub ahead of print. PMID: 33620043. 2: Pham DNK, Chadeayne AR, Golen JA, Manke DR. 2,5-Di-methyl-bufo-tenine and 2,5-di-methyl-bufo-teni-dine: novel derivatives of natural tryptamines found in Bufo alvarius toads. Acta Crystallogr E Crystallogr Commun. 2021 Jan 29;77(Pt 2):190-194. doi: 10.1107/S2056989021000803. PMID: 33614152; PMCID: PMC7869544. 3: Pham DNK, Chadeayne AR, Golen JA, Manke DR. Psilacetin derivatives: fumarate salts of the meth-yl-ethyl, meth-yl-allyl and diallyl variants of the psilocin prodrug. Acta Crystallogr E Crystallogr Commun. 2021 Jan 8;77(Pt 2):101-106. doi: 10.1107/S2056989021000116. PMID: 33614134; PMCID: PMC7869532. 4: Wang W, Gao J. Effects of melatonin on protecting against lung injury (Review). Exp Ther Med. 2021 Mar;21(3):228. doi: 10.3892/etm.2021.9659. Epub 2021 Jan 20. PMID: 33603837; PMCID: PMC7851611. 5: Nayak A, Saxena H, Bathula C, Kumar T, Bhattacharjee S, Sen S, Gupta A. Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum. Malar J. 2021 Feb 17;20(1):100. doi: 10.1186/s12936-021-03632-2. PMID: 33596950; PMCID: PMC7891021. 6: Dopkins N, Becker W, Miranda K, Walla M, Nagarkatti P, Nagarkatti M. Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Front Pharmacol. 2021 Jan 25;11:619265. doi: 10.3389/fphar.2020.619265. PMID: 33569008; PMCID: PMC7868334. 7: Zhang Y, Dijkman PM, Zou R, Zandl-Lang M, Sanchez RM, Eckhardt-Strelau L, Köfeler H, Vogel H, Yuan S, Kudryashev M. Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers. Nat Commun. 2021 Feb 16;12(1):1074. doi: 10.1038/s41467-021-21016-7. PMID: 33594077. 8: Balaji TM, Rao SR. Salivary, Plasma, and Gingival Levels of Melatonin and TNF-α in Nonsmokers and Current Smokers with and without Periodontal Disease. J Contemp Dent Pract. 2020 Aug 1;21(8):897-904. PMID: 33568612. 9: Pallavicini C, Cavanna F, Zamberlan F, de la Fuente LA, Ilksoy Y, Perl YS, Arias M, Romero C, Carhart-Harris R, Timmermann C, Tagliazucchi E. Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings. J Psychopharmacol. 2021 Feb 10:269881120981384. doi: 10.1177/0269881120981384. Epub ahead of print. PMID: 33567945. 10: Markin PA, Brito A, Moskaleva NE, Tagliaro F, La Frano MR, Savitskii MV, Appolonova SA. Short- and long-term exposures of the synthetic cannabinoid 5F-APINAC induce metabolomic alterations associated with neurotransmitter systems and embryotoxicity confirmed by teratogenicity in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2021 May;243:109000. doi: 10.1016/j.cbpc.2021.109000. Epub 2021 Feb 6. PMID: 33561556. 11: Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC, Cheikh A, Jalali F, Boilard E, Flamand L. Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19. Blood Adv. 2021 Feb 9;5(3):635-639. doi: 10.1182/bloodadvances.2020003513. PMID: 33560374; PMCID: PMC7846461. 12: Tata A, Pallante I, Massaro A, Miano B, Bottazzari M, Fiorini P, Dal Prà M, Paganini L, Stefani A, De Buck J, Piro R, Pozzato N. Serum Metabolomic Profiles of Paratuberculosis Infected and Infectious Dairy Cattle by Ambient Mass Spectrometry. Front Vet Sci. 2021 Jan 20;7:625067. doi: 10.3389/fvets.2020.625067. PMID: 33553289; PMCID: PMC7854907. 13: Hagino Y, Hall FS, Uhl GR, Sora I, Ikeda K. Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex. Neuropsychopharmacol Rep. 2021 Feb 6. doi: 10.1002/npr2.12161. Epub ahead of print. PMID: 33547882. 14: Wu H, Yang J, Shen P, Li Q, Wu W, Jiang X, Qin L, Huang J, Cao X, Qi F. High-Level Production of Indole-3-acetic Acid in the Metabolically Engineered Escherichia coli. J Agric Food Chem. 2021 Feb 17;69(6):1916-1924. doi: 10.1021/acs.jafc.0c08141. Epub 2021 Feb 4. PMID: 33541074. 15: Torres D, Mongiardini E, Donadío F, Donoso R, Recabarren-Gajardo G, Gualpa J, Spaepen S, Defez R, Lopez G, Bianco C, Cassán F. Molecular and physiological analysis of indole-3-acetic acid degradation in Bradyrhizobium japonicum E109. Res Microbiol. 2021 Feb 1:103814. doi: 10.1016/j.resmic.2021.103814. Epub ahead of print. PMID: 33539931. 16: Özdemir Z, Alagöz MA, Bahçecioğlu ÖF, Gök S. Monoamineoxidase-B (MAO-B) Inhibitors in theTreatment of Alzheimer's and Parkinson's Disease. Curr Med Chem. 2021 Feb 3. doi: 10.2174/0929867328666210203204710. Epub ahead of print. PMID: 33538661. 17: Mendiguren A, Aostri E, Pineda J. Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence. Adv Exp Med Biol. 2021;1297:111-132. doi: 10.1007/978-3-030-61663-2_8. PMID: 33537940. 18: Morales P, Jagerovic N. Synthetic and Natural Derivatives of Cannabidiol. Adv Exp Med Biol. 2021;1297:11-25. doi: 10.1007/978-3-030-61663-2_2. PMID: 33537934. 19: Pahalagedara ASNW, Flint S, Palmer J, Subbaraj A, Brightwell G, Gupta TB. Antimicrobial Activity of Soil Clostridium Enriched Conditioned Media Against Bacillus mycoides, Bacillus cereus, and Pseudomonas aeruginosa. Front Microbiol. 2020 Dec 4;11:608998. doi: 10.3389/fmicb.2020.608998. PMID: 33343553; PMCID: PMC7746556. 20: Simonetti G, Boga C, Durante J, Micheletti G, Telese D, Caruana P, Ghelli Luserna di Rorà A, Mantellini F, Bruno S, Martinelli G, Calonghi N. Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents. Molecules. 2021 Jan 28;26(3):683. doi: 10.3390/molecules26030683. PMID: 33525621; PMCID: PMC7865355.