JNJ-78394355 | CAS# | Mcl-1 inhibitor

MedKoo Cat#: 123389 | Name: JNJ-78394355

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-78394355 is a Mcl-1 inhibitor.

Chemical Structure

JNJ-78394355

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123389

Name: JNJ-78394355

CAS#: N/A

Chemical Formula: C40H44ClN5O5S

Exact Mass: 741.2800

Molecular Weight: 742.33

Elemental Analysis: C, 64.72; H, 5.97; Cl, 4.78; N, 9.43; O, 10.78; S, 4.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JNJ-78394355; JNJ 78394355; JNJ78394355

IUPAC/Chemical Name

(Z)-15-chloro-21-(2-(2-methoxyethoxy)ethyl)-13,23,61-trimethyl-11H,21H,61H-10-oxa-4-thia-1(4,1)-indola-2(4,5),6(3,5)-dipyrazola-9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid

InChi Key

WREPOKHXPHVMBY-UHFFFAOYSA-N

InChi Code

InChI=1S/C40H44ClN5O5S/c1-25-36-33-13-12-32(41)38(36)37-26(2)42-46(15-17-50-19-18-49-4)34(37)24-52-23-29-22-30(44(3)43-29)11-10-27-20-28-8-5-6-9-31(28)35(21-27)51-16-7-14-45(33)39(25)40(47)48/h5-6,8-9,12-13,20-22H,7,10-11,14-19,23-24H2,1-4H3,(H,47,48)

SMILES Code

CC1=NN(CCOCCOC)C(CSC2)=C1C3=C(C4=CC=C3Cl)C(C)=C(C(O)=O)N4CCCOC5=CC(CCC6=CC2=NN6C)=CC7=C5C=CC=C7

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 742.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies Fedor Romanov-Michailidis, Chien-Chi Hsiao, Lorenz M. Urner, Soufyan Jerhaoui, Michel Surkyn, Bradley Miller, Ann Vos, Maria Dominguez Blanco, Ruud Bueters, Petra Vinken, Mariette Bekkers, David Walker, Beth Pietrak, Werner Eyckmans, José Luís Dores-Sousa, Seong Joo Koo, William Lento, Marcus Bauser, Ulrike Philippar, and Frederik J. R. Rombouts Journal of Medicinal Chemistry Article ASAP DOI: 10.1021/acs.jmedchem.2c01953