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MedKoo Cat#: 563872 | Name: NAB-14
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAB-14 is a selective negative allosteric modulator (NAM) for GluN2C/2D-containing NMDA receptors. NAB-14 inhibits synaptic transmission in hippocampal interneurons.

Chemical Structure

NAB-14
NAB-14
CAS#1237541-73-9

Theoretical Analysis

MedKoo Cat#: 563872

Name: NAB-14

CAS#: 1237541-73-9

Chemical Formula: C20H21N3O3

Exact Mass: 351.1583

Molecular Weight: 351.41

Elemental Analysis: C, 68.36; H, 6.02; N, 11.96; O, 13.66

Price and Availability

Size Price Availability Quantity
5mg USD 230.00 2 Weeks
10mg USD 370.00 2 Weeks
25mg USD 620.00 2 Weeks
50mg USD 1,050.00 2 Weeks
100mg USD 1,500.00 2 Weeks
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Related CAS #
No Data
Synonym
NAB-14; NAB14; NAB 14
IUPAC/Chemical Name
4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate
InChi Key
WCGIKJOMEYPSIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
SMILES Code
O=C(OC1=CC=C(C(NC2=CC=CC3=C2NC=C3)=O)C=C1)N(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. PubMed PMID: 29043770; PubMed Central PMCID: PMC5924706.