Olorofim | CAS#1928707-56-5 | Antifungal

MedKoo Cat#: 208183 | Name: Olorofim

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Olorofim , also known as F-901318, is a newly developed antifungal compound that targets pyrimidine biosynthesis in molds. In light of the in vitro and in vivo activity of olorofim against dermatophytes, this novel agent may be considered as a treatment of choice against dermatophytosis.

Chemical Structure

Olorofim

CAS#1928707-56-5

Theoretical Analysis

MedKoo Cat#: 208183

Name: Olorofim

CAS#: 1928707-56-5

Chemical Formula: C28H27FN6O2

Exact Mass: 498.2180

Molecular Weight: 498.56

Elemental Analysis: C, 67.46; H, 5.46; F, 3.81; N, 16.86; O, 6.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

F-901318; F 901318 F901318; Olorofim;

IUPAC/Chemical Name

2-(1,5-Dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide

InChi Key

SUFPWYYDCOKDLL-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)

SMILES Code

O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 498.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hoenigl M, Sprute R, Egger M, Arastehfar A, Cornely OA, Krause R, Lass-Flörl C, Prattes J, Spec A, Thompson GR 3rd, Wiederhold N, Jenks JD. The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin. Drugs. 2021 Oct;81(15):1703-1729. doi: 10.1007/s40265-021-01611-0. Epub 2021 Oct 9. PMID: 34626339; PMCID: PMC8501344. 2: Mirbzadeh Ardakani E, Sharifirad A, Pashootan N, Nayebhashemi M, Zahmatkesh M, Enayati S, Razzaghi-Abyaneh M, Khalaj V. Olorofim Effectively Eradicates Dermatophytes In Vitro and In Vivo. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0138621. doi: 10.1128/AAC.01386-21. Epub 2021 Sep 27. PMID: 34570652; PMCID: PMC8597723. 3: Wiederhold NP. Review of the Novel Investigational Antifungal Olorofim. J Fungi (Basel). 2020 Jul 30;6(3):122. doi: 10.3390/jof6030122. PMID: 32751765; PMCID: PMC7557671. 4: Seyedmousavi S, Chang YC, Youn JH, Law D, Birch M, Rex JH, Kwon-Chung KJ. In Vivo Efficacy of Olorofim against Systemic Scedosporiosis and Lomentosporiosis. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0043421. doi: 10.1128/AAC.00434-21. Epub 2021 Jul 12. PMID: 34252298; PMCID: PMC8448127. 5: Astvad KMT, Jørgensen KM, Hare RK, Datcu R, Arendrup MC. Olorofim Susceptibility Testing of 1,423 Danish Mold Isolates Obtained in 2018-2019 Confirms Uniform and Broad-Spectrum Activity. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01527-20. doi: 10.1128/AAC.01527-20. PMID: 33020160; PMCID: PMC7927864. 6: Badali H, Cañete-Gibas C, Patterson H, Sanders C, Mermella B, Garcia V, Mele J, Fan H, Wiederhold NP. In vitro activity of olorofim against clinical isolates of the Fusarium oxysporum and Fusarium solani species complexes. Mycoses. 2021 Jul;64(7):748-752. doi: 10.1111/myc.13273. Epub 2021 Apr 4. PMID: 33755988. 7: Georgacopoulos O, Nunnally NS, Ransom EM, Law D, Birch M, Lockhart SR, Berkow EL. In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents. J Fungi (Basel). 2021 May 12;7(5):378. doi: 10.3390/jof7050378. PMID: 34065811; PMCID: PMC8150786. 8: Su H, Zhu M, Tsui CK, van der Lee H, Tehupeiory-Kooreman M, Zoll J, Engel T, Li L, Zhu J, Lu Z, Zhang Q, Verweij PE, Deng S. Potency of olorofim (F901318) compared to contemporary antifungal agents against clinical Aspergillus fumigatus isolates, and review of azole resistance phenotype and genotype epidemiology in China. Antimicrob Agents Chemother. 2021 Mar 8;65(5):e02546-20. doi: 10.1128/AAC.02546-20. Epub ahead of print. PMID: 33685896; PMCID: PMC8092882. 9: Rivero-Menendez O, Cuenca-Estrella M, Alastruey-Izquierdo A. In vitro activity of olorofim against clinical isolates of Scedosporium species and Lomentospora prolificans using EUCAST and CLSI methodologies. J Antimicrob Chemother. 2020 Dec 1;75(12):3582-3585. doi: 10.1093/jac/dkaa351. PMID: 32856079. 10: Zhang J, Liu H, Xi L, Chang YC, Kwon-Chung KJ, Seyedmousavi S. Antifungal Susceptibility Profiles of Olorofim (Formerly F901318) and Currently Available Systemic Antifungals against Mold and Yeast Phases of Talaromyces marneffei. Antimicrob Agents Chemother. 2021 May 18;65(6):e00256-21. doi: 10.1128/AAC.00256-21. PMID: 33753341; PMCID: PMC8316025.