JNJ-6204 | CAS#2765264-50-2 | CSNK1D/CSNK1E inhibitor

MedKoo Cat#: 130128 | Name: JNJ-6204

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).

Chemical Structure

JNJ-6204

CAS#2765264-50-2

Theoretical Analysis

MedKoo Cat#: 130128

Name: JNJ-6204

CAS#: 2765264-50-2

Chemical Formula: C19H11D6FN6O

Exact Mass: 370.1824

Molecular Weight: 370.42

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.61; H, 6.26; F, 5.13; N, 22.69; O, 4.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JNJ-6204; JNJ6204; JNJ 6204

IUPAC/Chemical Name

2-(5-fluoropyridin-2-yl)-6,6-bis(methyl-d3)-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine

InChi Key

WZMIWVZGYMKUDV-WFGJKAKNSA-N

InChi Code

InChI=1S/C19H17FN6O/c1-19(2)10-26-15(9-27-19)16(12-5-6-21-18-13(12)8-23-24-18)17(25-26)14-4-3-11(20)7-22-14/h3-8H,9-10H2,1-2H3,(H,21,23,24)/i1D3,2D3

SMILES Code

[2H]C(C(OC1)(C([2H])([2H])[2H])CN2C1=C(C3=C4C(NN=C4)=NC=C3)C(C5=NC=C(F)C=C5)=N2)([2H])[2H]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Increased CSNK1D expression/activity plays an important role in the pathology of certain cancers, metabolic processes, neurodegenerative diseases, and mood/psychiatric disorders.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. https://patents.google.com/patent/WO2022058920A1/en 2. https://www.eubopen.org/sites/www.eubopen.org/files/chemical-probes/EUbOPEN_ProbeSheet_JNJ-6204_v1.pdf