MedKoo Cat#: 465435 | Name: NAH-C3-GPKK

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAH-C3-GPKK is a novel potent protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibitor (Ki, app = 7 ± 1 nM), also potently inhibiting a methyltransferase complex HemK2-Trm112 (also known as KMT9-Trm112).

Chemical Structure

NAH-C3-GPKK
NAH-C3-GPKK
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465435

Name: NAH-C3-GPKK

CAS#: unknown

Chemical Formula: C36H60N13O10

Exact Mass: 834.4586

Molecular Weight: 834.96

Elemental Analysis: C, 51.79; H, 7.24; N, 21.81; O, 19.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
NAH-C3-GPKK; NAHC3-GPKK; NAH C3-GPKK; NAH-C3GPKK; NAH-C3 GPKK; NAHC3GPKK; NAH C3 GPKK;
IUPAC/Chemical Name
((S)-2-((S)-1-((3-(((S)-3-amino-3-carboxypropyl)(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)propyl)glycyl)pyrrolidine-2-carboxamido)-6-(l2-azanyl)hexanoyl)-L-lysine
InChi Key
VRMGOZNKLJUBCO-UNWCPZPISA-N
InChi Code
InChI=1S/C36H60N13O10/c37-11-3-1-7-22(32(53)46-23(36(57)58)8-2-4-12-38)45-33(54)24-9-5-15-48(24)26(50)17-41-13-6-14-47(16-10-21(39)35(55)56)18-25-28(51)29(52)34(59-25)49-20-44-27-30(40)42-19-43-31(27)49/h19-25,28-29,34,37,41,51-52H,1-18,38-39H2,(H,45,54)(H,46,53)(H,55,56)(H,57,58)(H2,40,42,43)/t21-,22-,23-,24-,25+,28+,29+,34+/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@@H](NC([C@H]1N(C(CNCCCN(CC[C@H](N)C(O)=O)C[C@H]2O[C@@H](N3C=NC4=C(N)N=CN=C34)[C@H](O)[C@@H]2O)=O)CCC1)=O)CCCC[NH])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 834.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen D, Meng Y, Yu D, Noinaj N, Cheng X, Huang R. Chemoproteomic Study Uncovers HemK2/KMT9 As a New Target for NTMT1 Bisubstrate Inhibitors. ACS Chem Biol. 2021 Jul 16;16(7):1234-1242. doi: 10.1021/acschembio.1c00279. Epub 2021 Jun 30. PMID: 34192867; PMCID: PMC8286339.