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MedKoo Cat#: 465378 | Name: PB01

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PB01 is a novel regulator of ATR signaling in human non-small-cell lung cancer cells, suppressing radio-resistance.

Chemical Structure

PB01
PB01
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465378

Name: PB01

CAS#: unknown

Chemical Formula: C21H25N3O3S2

Exact Mass: 431.1337

Molecular Weight: 431.57

Elemental Analysis: C, 58.45; H, 5.84; N, 9.74; O, 11.12; S, 14.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PB01; PB 01; PB-01;
IUPAC/Chemical Name
(1r,4r)-N-(2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)benzo[d]thiazol-6-yl)-4-methoxycyclohexane-1-carboxamide
InChi Key
KJOGJXCKVVWILY-KOMQPUFPSA-N
InChi Code
InChI=1S/C21H25N3O3S2/c1-12-17(13(2)27-24-12)11-28-21-23-18-9-6-15(10-19(18)29-21)22-20(25)14-4-7-16(26-3)8-5-14/h6,9-10,14,16H,4-5,7-8,11H2,1-3H3,(H,22,25)/t14-,16-
SMILES Code
O=C(NC1=CC(SC(SCC2=C(C)ON=C2C)=N3)=C3C=C1)[C@@H]4CC[C@@H](OC)CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim TW, Hong DW, Hong SH. PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells. Sci Rep. 2021 Jun 8;11(1):12093. doi: 10.1038/s41598-021-91716-z. PMID: 34103635; PMCID: PMC8187425.

View History

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