Synonym
Etoperidone Free Base; Etoperidona; Etoperidonum
IUPAC/Chemical Name
1,2,4-Triazol-3-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-
InChi Key
IZBNNCFOBMGTQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3
SMILES Code
O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
377.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Costa A, Martignoni E, Blandini F, Petraglia F, Genazzani AR, Nappi G. Effects of etoperidone on sympathetic and pituitary-adrenal responses to diverse stressors in humans. Clin Neuropharmacol. 1993 Apr;16(2):127-38. doi: 10.1097/00002826-199304000-00005. PMID: 8386590.
2: Raffa RB, Shank RP, Vaught JL. Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology (Berl). 1992;108(3):320-6. doi: 10.1007/BF02245118. PMID: 1387963.
3: Przegaliński E, Lewandowska A. The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system. J Neural Transm. 1979;46(4):303-12. doi: 10.1007/BF01259336. PMID: 529000.
4: Yan Z, Caldwell GW, Wu WN, McKown LA, Rafferty B, Jones W, Masucci JA. In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62. doi: 10.1080/00498250210163298. PMID: 12487725.
5: Caldwell GW, Wu WN, Masucci JA. Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man. Xenobiotica. 2001 Nov;31(11):823-39. doi: 10.1080/00498250110091758. PMID: 11765144.
6: Danilov DS. Mul'timodal'nye serotoninergicheskie antidepressanty [Multimodal serotonergic antidepressants]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(9):103-111. Russian. doi: 10.17116/jnevro201711791103-111. PMID: 29053130.
7: Martínez MA, Sánchez de la Torre C, Almarza E. A comparative solid-phase extraction study for the simultaneous determination of fluvoxamine, mianserin, doxepin, citalopram, paroxetine, and etoperidone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection. J Anal Toxicol. 2004 Apr;28(3):174-80. doi: 10.1093/jat/28.3.174. PMID: 15107147.
8: Lisciani R, Baldini A, Benedetti D, Campana A, Barcellona PS. Acute cardiovascular toxicity of trazodone, etoperidone and imipramine in rats. Toxicology. 1978 Jun;10(2):151-8. doi: 10.1016/0300-483x(78)90065-3. PMID: 684760.
9: Melzacka M, Rurak A, Vetulani J. Preliminary study of the biotransformation of two new drugs, trazodone and etoperidone. Pol J Pharmacol Pharm. 1980 Jul- Aug;32(4):551-6. PMID: 7255270.
10: Cioli V, Corradino C, Piccinelli D, Rocchi MG, Valeri P. A comparative pharmacological study of trazodone, etoperidone and 1-(m-chlorophenyl)piperazine. Pharmacol Res Commun. 1984 Jan;16(1):85-100. PMID: 6701182.
